TTD | Drug: D0R7WU

Drug General Information
Drug ID	D0R7WU
Former ID	DNC012502
Drug Name	ACECLIDINE
Drug Type	Small molecular drug
Indication	Glaucoma [ICD9: 365; ICD10:H40-H42]		Approved	[539906], [551871]
Formula	C9H16NO2+
InChI	InChI=1S/C9H15NO2/c1-7(11)12-9-6-10-4-2-8(9)3-5-10/h8-9H,2-6H2,1H3/p+1/t9-/m0/s1
InChIKey	WRJPSSPFHGNBMG-VIFPVBQESA-O
CAS Number	CAS 827-61-2
PubChem Compound ID	6979053
PubChem Substance ID	1579904, 43583458, 50815213, 135649886, 223470074
SuperDrug ATC ID	S01EB08
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M5	Target Info	Inhibitor	[534044]
	Muscarinic acetylcholine receptor M4	Target Info	Inhibitor	[534044]
	Muscarinic acetylcholine receptor M3	Target Info	Inhibitor	[534044]
	Muscarinic acetylcholine receptor M1	Target Info	Inhibitor	[534044]
	Muscarinic acetylcholine receptor M2	Target Info	Inhibitor	[534044]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Regulation of actin cytoskeletonhsa04080:Neuroactive ligand-receptor interaction
	Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
	Regulation of actin cytoskeleton
	Insulin secretion
	Salivary secretion
	Gastric acid secretion
	Pancreatic secretionhsa04020:Calcium signaling pathway
	cAMP signaling pathway
	PI3K-Akt signaling pathway
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway	Gastric Acid ProductionPW000564:Muscle/Heart Contraction
Reactome	Muscarinic acetylcholine receptors
	G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	G alpha (i) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	Acetylcholine regulates insulin secretion
	G alpha (i) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signalingWP58:Monoamine GPCRs
	Integration of energy metabolism
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR downstream signalingWP706:SIDS Susceptibility Pathways
	GPCRs, Other
References
Ref 539906	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 288).
Ref 551871	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 534044	J Med Chem. 1993 Apr 2;36(7):842-7.Design, synthesis, and neurochemical evaluation of 5-(3-alkyl-1,2,4- oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidines as M1 muscarinic receptor agonists.

Drug Information