Drug Information

Drug General Information
Drug ID
D0KS6W
Former ID
DNC005180
Drug Name
Phenyltoloxamine
Drug Type
Small molecular drug
Indication Allergy [ICD9: 995.3; ICD10:T78.4] Approved [551871]
Formula
C17H22ClNO
Canonical SMILES
CN(C)CCOC1=CC=CC=C1CC2=CC=CC=C2
InChI
1S/C17H21NO/c1-18(2)12-13-19-17-11-7-6-10-16(17)14-15-8-4-3-5-9-15/h3-11H,12-14H2,1-2H3
InChIKey
IZRPKIZLIFYYKR-UHFFFAOYSA-N
CAS Number
CAS 92-12-6
PubChem Compound ID
22528
Target and Pathway
Target(s) Dopamine D1 receptor Target Info Inhibitor [527160]
D(4) dopamine receptor Target Info Inhibitor [527160]
D(2) dopamine receptor Target Info Inhibitor [527160]
D(1B) dopamine receptor Target Info Inhibitor [527160]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Alcoholismhsa04080:Neuroactive ligand-receptor interaction
Dopaminergic synapsehsa04015:Rap1 signaling pathway
Alcoholismhsa04020:Calcium signaling pathway
PANTHER Pathway Dopamine receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (s) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signalingWP666:Hypothetical Network for Drug Addiction
GPCR downstream signaling
Nicotine Activity on Dopaminergic Neurons
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Nicotine Activity on Dopaminergic NeuronsWP58:Monoamine GPCRs
References
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 527160J Med Chem. 2004 Aug 12;47(17):4155-8.Dopamine/serotonin receptor ligands. 9. Oxygen-containing midsized heterocyclic ring systems and nonrigidized analogues. A step toward dopamine D5 receptor selectivity.