Drug Information

Drug General Information
Drug ID
D0I8RR
Former ID
DAP000984
Drug Name
Streptozocin
Synonyms
Estreptozocina; STREPTOZOTOCIN; STRZ; Streptozocine; Streptozocinium; Streptozocinum; Streptozosin; Zanosar; Alkylating agent; Binds to DNA; Streptozocinium [Latin]; Streptozocine [INN-French]; Streptozocinum [INN-Latin]; Zanosar (TN); Streptozocin (USAN/INN); Streptozocin, Zanosar, STZ,Streptozotocin;N-(Methylnitrosocarbamoyl)-alpha-D-glucosamine; N-D-Glucosyl-(2)-N'-nitrosomethylharnstoff; N-D-Glucosyl-(2)-N'-nitrosomethylurea; D-Glucose, 2-deoxy-2-(((methylnitrosoamino)carbonyl)amino)-(9CI); 1-methyl-1-nitroso-3-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea; 2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose; 2-Deoxy-2[[(methylnitrosoamino)-carbonyl]amino]-D-glucopyranose; 2-deoxy-2-{[methyl(nitroso)carbamoyl]amino}-alpha-D-glucopyranose
Drug Type
Small molecular drug
Indication Metastatic islet cell carcinoma [ICD9: 157.4; ICD10:C25.4] Approved [536361]
Therapeutic Class
Anticancer Agents
Company
Pfizer Pharmaceuticals
Formula
C8H15N3O7
Canonical SMILES
CN(C(=O)NC1C(C(C(OC1O)CO)O)O)N=O
InChI
1S/C8H15N3O7/c1-11(10-17)8(16)9-4-6(14)5(13)3(2-12)18-7(4)15/h3-7,12-15H,2H2,1H3,(H,9,16)/t3-,4-,5-,6-,7+/m1/s1
InChIKey
ZSJLQEPLLKMAKR-GKHCUFPYSA-N
CAS Number
CAS 18883-66-4
PubChem Compound ID
29327
PubChem Substance ID
9521, 596509, 7980678, 8149530, 8170920, 11335706, 11360945, 11363854, 11366416, 11368978, 11372053, 11374906, 11377140, 11461917, 11483979, 11487878, 11490902, 11493058, 11494774, 11534179, 12173581, 24899428, 26611922, 26679870, 34671698, 46508872, 47207590, 47515288, 47588962, 47662248, 47736441, 47959704, 48110424, 48184964, 48334456, 48414469, 48416558, 49699154, 50123151, 50123152, 53789885, 56311248, 56311776, 56314572, 57288842, 57310788, 57654595, 79254669, 92124251, 92307679
ChEBI ID
ChEBI:9288
SuperDrug ATC ID
L01AD04
SuperDrug CAS ID
cas=018883664
Target and Pathway
Target(s) DNA Target Info Breaker [537542]
References
Ref 536361Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20.
Ref 537542Hydrodynamics-based Transfection of Pancreatic Duodenal Homeobox 1 DNA Improves Hyperglycemia and is Associated with Limited Complications in Diabetic mice. Endocr J. 2009 Jun 27.