TTD | Drug: D05AJT

Drug General Information
Drug ID	D05AJT
Former ID	DCL001038
Drug Name	XL019
Drug Type	Small molecular drug
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Phase 3	[532295], [542887]
Indication	Polycythemia vera [ICD9: 238.4; ICD10:D45]		Phase 1	[537520], [542887]
Formula	C25H28N6O2
InChIKey	ISOCDPQFIXDIMS-QHCPKHFHSA-N
PubChem Compound ID	57990869
PubChem Substance ID	138051907, 163642972, 163771181, 171061158, 198942749, 210274974, 210280612, 223401962, 226088072, 230317007, 248406690, 249565654, 252160842, 252216623, 252442045, 252473906
Target and Pathway
Target(s)	Tyrosine-protein kinase JAK2	Target Info	Inhibitor	[537520]
KEGG Pathway	Chemokine signaling pathway
	PI3K-Akt signaling pathway
	Signaling pathways regulating pluripotency of stem cells
	Jak-STAT signaling pathway
	Cholinergic synapse
	Prolactin signaling pathway
	Adipocytokine signaling pathway
	Leishmaniasis
	Toxoplasmosis
	Tuberculosis
	Measles
	Influenza A
	Herpes simplex infection
PANTHER Pathway	Inflammation mediated by chemokine and cytokine signaling pathway
	Interferon-gamma signaling pathway
	JAK/STAT signaling pathway
	PDGF signaling pathway
	PI3 kinase pathway
	CCKR signaling map ST
Pathway Interaction Database	Endothelins
	ErbB4 signaling events
	GMCSF-mediated signaling events
	IL4-mediated signaling events
	IL27-mediated signaling events
	Signaling events mediated by PTP1B
	IL12-mediated signaling events
	S1P3 pathway
	SHP2 signaling
	CXCR4-mediated signaling events
	IL5-mediated signaling events
	IFN-gamma pathway
	ErbB2/ErbB3 signaling events
	IL3-mediated signaling events
	IL6-mediated signaling events
	PDGFR-beta signaling pathway
	IL23-mediated signaling events
	Signaling events mediated by Stem cell factor receptor (c-Kit)
	EPO signaling pathway
	Notch-mediated HES/HEY network
Reactome	Interleukin-6 signaling
	MAPK3 (ERK1) activation
	MAPK1 (ERK2) activation
	GPVI-mediated activation cascade
	Prolactin receptor signaling
	RMTs methylate histone arginines
	G beta:gamma signalling through PI3Kgamma
	Interleukin-3, 5 and GM-CSF signaling
	RAF activation
	RAF/MAP kinase cascade
	Interferon gamma signaling
	Regulation of IFNG signaling
	Interleukin receptor SHC signaling
	Growth hormone receptor signaling
	Factors involved in megakaryocyte development and platelet production
WikiPathways	Serotonin Receptor 2 and STAT3 Signaling
	Type II interferon signaling (IFNG)
	Notch Signaling Pathway
	EPO Receptor Signaling
	EGF/EGFR Signaling Pathway
	IL-4 Signaling Pathway
	IL-6 signaling pathway
	Kit receptor signaling pathway
	IL-3 Signaling Pathway
	Mesodermal Commitment Pathway
	Interleukin-2 signaling
	Signaling by SCF-KIT
	Prolactin receptor signaling
	Growth hormone receptor signaling
	JAK/STAT
	BDNF signaling pathway
	Oncostatin M Signaling Pathway
	Interleukin-11 Signaling Pathway
	AGE/RAGE pathway
	TSLP Signaling Pathway
	IL17 signaling pathway
	Leptin signaling pathway
	TSH signaling pathway
	Interleukin-3, 5 and GM-CSF signaling
	Interferon gamma signaling
	Factors involved in megakaryocyte development and platelet production
	IL-5 Signaling Pathway
References
Ref 532295	Update on JAK2 Inhibitors in Myeloproliferative Neoplasm. Ther Adv Hematol. 2011 Apr;2(2):61-71.
Ref 537520	Emerging drugs for the therapy of primary and post essential thrombocythemia, post polycythemia vera myelofibrosis. Expert Opin Emerg Drugs. 2009 Jun 24.
Ref 542887	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7971).
Ref 537520	Emerging drugs for the therapy of primary and post essential thrombocythemia, post polycythemia vera myelofibrosis. Expert Opin Emerg Drugs. 2009 Jun 24.

Drug Information