TTD | Drug: D04DDM

Drug General Information
Drug ID	D04DDM
Former ID	DNC000812
Drug Name	ISIS 3521
Drug Type	Antisense drug
Indication	Discovery agent		Discontinued in Phase 2	[546108]
Therapeutic Class	Antisense
CAS Number	CAS 107420-91-7
SuperDrug ATC ID	D03AX10
SuperDrug CAS ID	cas=000471534
Target and Pathway
Target(s)	Protein kinase C, alpha type	Target Info	Modulator
KEGG Pathway	MAPK signaling pathway
	ErbB signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	HIF-1 signaling pathway
	Phosphatidylinositol signaling system
	Sphingolipid signaling pathway
	mTOR signaling pathway
	PI3K-Akt signaling pathway
	Adrenergic signaling in cardiomyocytes
	Vascular smooth muscle contraction
	Wnt signaling pathway
	VEGF signaling pathway
	Focal adhesion
	Tight junction
	Gap junction
	Natural killer cell mediated cytotoxicity
	Fc epsilon RI signaling pathway
	Fc gamma R-mediated phagocytosis
	Leukocyte transendothelial migration
	Circadian entrainment
	Long-term potentiation
	Retrograde endocannabinoid signaling
	Glutamatergic synapse
	Cholinergic synapse
	Serotonergic synapse
	GABAergic synapse
	Dopaminergic synapse
	Long-term depression
	Inflammatory mediator regulation of TRP channels
	Insulin secretion
	GnRH signaling pathway
	Melanogenesis
	Thyroid hormone synthesis
	Thyroid hormone signaling pathway
	Oxytocin signaling pathway
	Aldosterone-regulated sodium reabsorption
	Endocrine and other factor-regulated calcium reabsorption
	Salivary secretion
	Gastric acid secretion
	Pancreatic secretion
	Amphetamine addiction
	Morphine addiction
	Vibrio cholerae infection
	Pathogenic Escherichia coli infection
	African trypanosomiasis
	Amoebiasis
	Hepatitis B
	Influenza A
	Pathways in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
	Glioma
	Non-small cell lung cancer
	Choline metabolism in cancer
NetPath Pathway	IL2 Signaling Pathway
PANTHER Pathway	Alpha adrenergic receptor signaling pathway
	Alzheimer disease-amyloid secretase pathway
	Angiogenesis
	Apoptosis signaling pathway
	EGF receptor signaling pathway
	Endothelin signaling pathway
	FGF signaling pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	PDGF signaling pathway
	VEGF signaling pathway
	Wnt signaling pathway
	5HT2 type receptor mediated signaling pathway
	Histamine H1 receptor mediated signaling pathway
	Oxytocin receptor mediated signaling pathway
	Thyrotropin-releasing hormone receptor signaling pathway
	Angiotensin II-stimulated signaling through G proteins and beta-arrestin
	CCKR signaling map ST
Pathway Interaction Database	Endothelins
	TCR signaling in na&#xef
	Canonical NF-kappaB pathway
	Signaling events regulated by Ret tyrosine kinase
	TCR signaling in na&#xef
	Thromboxane A2 receptor signaling
	Role of Calcineurin-dependent NFAT signaling in lymphocytes
	mTOR signaling pathway
	Ras signaling in the CD4+ TCR pathway
	ErbB1 downstream signaling
	Syndecan-4-mediated signaling events
	ATF-2 transcription factor network
	PDGFR-beta signaling pathway
	Retinoic acid receptors-mediated signaling
	IL8- and CXCR2-mediated signaling events
	VEGFR1 specific signals
	Signaling events mediated by VEGFR1 and VEGFR2
	PAR1-mediated thrombin signaling events
	a6b1 and a6b4 Integrin signaling
	IL8- and CXCR1-mediated signaling events
	Regulation of Ras family activation
	Downstream signaling in na&#xef
PathWhiz Pathway	Fc Epsilon Receptor I Signaling in Mast Cells
PathWhiz Pathway	Activation of PKC through G protein coupled receptor
Reactome	Calmodulin induced events
	Disinhibition of SNARE formation
	Regulation of KIT signaling
	EGFR Transactivation by Gastrin
	Inactivation, recovery and regulation of the phototransduction cascade
	Syndecan interactions
	Acetylcholine regulates insulin secretion
	Ca2+ pathway
	Trafficking of GluR2-containing AMPA receptors
	G alpha (z) signalling events
	Depolymerisation of the Nuclear Lamina
	HuR (ELAVL1) binds and stabilizes mRNA
	WNT5A-dependent internalization of FZD4
	VEGFR2 mediated cell proliferation
	Response to elevated platelet cytosolic Ca2+
WikiPathways	ErbB Signaling Pathway
	Calcium Regulation in the Cardiac Cell
	Insulin Signaling
	EGF/EGFR Signaling Pathway
	Wnt Signaling Pathway
	Wnt Signaling Pathway and Pluripotency
	Wnt Signaling Pathway Netpath
	G Protein Signaling Pathways
	Kit receptor signaling pathway
	Transcriptional activation by NRF2
	Myometrial Relaxation and Contraction Pathways
	Human Complement System
	Cardiac Hypertrophic Response
	Syndecan interactions
	Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
	Signaling by SCF-KIT
	DAG and IP3 signaling
	Gastrin-CREB signalling pathway via PKC and MAPK
	T-Cell Receptor and Co-stimulatory Signaling
	Alpha 6 Beta 4 signaling pathway
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	Oncostatin M Signaling Pathway
	Corticotropin-releasing hormone
	AGE/RAGE pathway
	Pathogenic Escherichia coli infection
	Signaling Pathways in Glioblastoma
	Endothelin Pathways
	Regulation of Microtubule Cytoskeleton
	FSH signaling pathway
	miRs in Muscle Cell Differentiation
	Opioid Signalling
	Response to elevated platelet cytosolic Ca2+
	Integration of energy metabolism
	TOR Signaling
References
Ref 546108	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800006393)

Drug Information