Drug Information

Drug General Information
Drug ID
D0A6PL
Former ID
DIB015804
Drug Name
S-14506
Drug Type
Small molecular drug
Indication Anxiety disorder [ICD9: 300, 311; ICD10:F32, F40-F42] Terminated [539527], [544866]
Company
Servier
Formula
C24H26FN3O2
InChI
InChI=1S/C24H26FN3O2/c1-30-21-10-7-18-3-2-4-23(22(18)17-21)28-15-13-27(14-16-28)12-11-26-24(29)19-5-8-20(25)9-6-19/h2-10,17H,11-16H2,1H3,(H,26,29)
InChIKey
IFMQODYDAUKKEN-UHFFFAOYSA-N
CAS Number
CAS 135721-98-1
PubChem Compound ID
131906
PubChem Substance ID
5851649, 10242995, 11114210, 14781681, 29310167, 78084415, 85209428, 104376199, 128160506, 135610559, 135650958, 135697706, 163143498, 177748534, 179149851, 223624044, 232094775, 242383891, 252159846
Target and Pathway
Target(s) 5-hydroxytryptamine 1A receptor Target Info Modulator
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 539527(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 24).
Ref 544866Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001368)