Drug Information

Drug General Information
Drug ID
D0P3IE
Former ID
DIB007303
Drug Name
ZK-93426
Drug Type
Small molecular drug
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Terminated [467684], [544909]
Company
Bayer Schering Pharma AG
Formula
C18H20N2O3
InChI
InChI=1S/C18H20N2O3/c1-5-22-18(21)17-11(4)15-13(9-19-17)20-12-7-6-8-14(16(12)15)23-10(2)3/h6-10,20H,5H2,1-4H3
InChIKey
VMDUABMKBUKKPG-UHFFFAOYSA-N
CAS Number
CAS 89592-45-0
PubChem Compound ID
115210
PubChem Substance ID
7980913, 10236685, 14752260, 26755020, 29296739, 50065365, 77957333, 85788682, 104397856, 123086151, 123108773, 129494685, 135072387, 137014559, 162224541, 178101164, 226553992
Target and Pathway
Target(s) GABA A receptor Target Info Modulator
KEGG Pathway Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Reactome Ligand-gated ion channel transport
GABA A receptor activation
WikiPathways SIDS Susceptibility Pathways
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Iron uptake and transport
References
Ref 467684(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4347).
Ref 544909Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001474)