Drug Information

Drug General Information
Drug ID
D06EDT
Former ID
DNC003650
Drug Name
ZOPOLRESTAT
Drug Type
Small molecular drug
Indication Diabetic complication [ICD10:E08-E13] Discontinued in Phase 2 [542443], [544806]
Formula
C19H12F3N3O3S
InChI
InChI=1S/C19H12F3N3O3S/c20-19(21,22)10-5-6-15-14(7-10)23-16(29-15)9-25-18(28)12-4-2-1-3-11(12)13(24-25)8-17(26)27/h1-7H,8-9H2,(H,26,27)
InChIKey
BCSVCWVQNOXFGL-UHFFFAOYSA-N
PubChem Compound ID
1613
PubChem Substance ID
4979, 4677841, 7849387, 7891237, 8151201, 12014107, 14719659, 14719661, 14719663, 14719739, 14719741, 14720015, 14720020, 14720022, 14758164, 24439936, 26705631, 26708405, 46516687, 49661426, 49661430, 49661434, 49661440, 49661448, 49661460, 50064154, 57320953, 78175922, 99445243, 103126043, 103170620, 104038222, 104298218, 111978541, 111978551, 112379023, 117504577, 126407157, 127496670, 134340855, 135018688, 137248745, 139060523, 140358853, 162103448, 162310032, 163305342, 163726884, 164194310, 178103991
Target and Pathway
Target(s) Aldose reductase Target Info Modulator
BioCyc Pathway Methylglyoxal degradation III
Acetone degradation I (to methylglyoxal)
KEGG Pathway Pentose and glucuronate interconversions
Fructose and mannose metabolism
Galactose metabolism
Glycerolipid metabolism
Metabolic pathways
NetPath Pathway IL1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Fructose and Mannose Degradation
Pyruvate Metabolism
Pterine Biosynthesis
Glycerolipid Metabolism
Galactose Metabolism
WikiPathways Metapathway biotransformation
Polyol Pathway
Metabolism of steroid hormones and vitamin D
References
Ref 542443(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7419).
Ref 544806Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001173)