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About
Drug Information
Drug General Information
Drug ID
D0A7KI
Former ID
DIB007980
Drug Name
Abaperidone
Synonyms
FI-8602
Drug Type
Small molecular drug
Indication
Schizophrenia [ICD9: 295; ICD10:F20]
Phase 1
[
551815
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Company
Ferrer Internacional SA
Formula
C25H25FN2O5
Canonical SMILES
n1c(c2c(o1)cc(cc2)F)C1CCN(CC1)CCCOc1cc2c(c(=O)c(co2)CO)<br />cc1
CAS Number
CAS 183849-43-6
PubChem Compound ID
3037308
Target and Pathway
Target(s)
5-hydroxytryptamine 2A receptor
Target Info
Modulator
[
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D(2) dopamine receptor
Target Info
Modulator
[
553290
]
KEGG Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04015:Rap1 signaling pathway
cAMP signaling pathway
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholism
PANTHER Pathway
5HT2 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathway
Reactome
Serotonin receptors
G alpha (q) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (i) signalling events
WikiPathways
Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP666:Hypothetical Network for Drug Addiction
Genes and (Common) Pathways Underlying Drug Addiction
Nicotine Activity on Dopaminergic Neurons
References
Ref 551815
Small Molecule Therapeutics for Schizophrenia, Sylvain Celanire. Page(30).
Ref 553290
7-[3-(1-piperidinyl)propoxy]chromenones as potential atypical antipsychotics. 2. Pharmacological profile of 7-[3-[4-(6-fluoro-1, 2-benzisoxazol-3-yl)-piperidin-1-yl]propoxy]-3-(hydroxymeth yl)chromen -4-one (abaperidone, FI-8602). J Med Chem. 1998 Dec 31;41(27):5402-9.
