Drug Information

Drug General Information
Drug ID
D0U3XL
Former ID
DIB000578
Drug Name
JNJ-26483327
Synonyms
MTKI (cancer), J&J; MTKI (cancer), Johnson & Johnson; Multi-targeted kinase inhibitor (cancer), J&J; Multi-targeted kinase inhibitor (cancer), Johnson & Johnson
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1 [522319]
Company
Johnson & Johnson
Canonical SMILES
c12c(cc3c(c1)c(ncn3)Nc1cc(ccc1CN(CCCCCO2)C)Br)OC
CAS Number
CAS 807640-87-5
Target and Pathway
Target(s) Lyn tyrosine kinase Target Info Inhibitor [550422]
Epidermal growth factor receptor Target Info Inhibitor [550422]
Vascular endothelial growth factor receptor 3 Target Info Inhibitor [550422]
Fyn tyrosine kinase Target Info Inhibitor [550423]
Receptor protein-tyrosine kinase erbB-2 Target Info Inhibitor [550422]
Lck tyrosine kinase Target Info Inhibitor [550422]
Proto-oncogene tyrosine-protein kinase Yes Target Info Inhibitor [550422]
Receptor protein-tyrosine kinase erbB-4 Target Info Inhibitor [550422]
KEGG Pathway Chemokine signaling pathway
NF-kappa B signaling pathway
Platelet activation
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Long-term depression
Epithelial cell signaling in Helicobacter pylori infection
Epstein-Barr virus infection
Viral carcinogenesishsa04010:MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
FoxO signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Dorso-ventral axis formation
Focal adhesion
Adherens junction
Gap junction
Regulation of actin cytoskeleton
GnRH signaling pathway
Estrogen signaling pathway
Oxytocin signaling pathway
Hepatitis C
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancerhsa04014:Ras signaling pathway
Focal adhesionhsa04071:Sphingolipid signaling pathway
Axon guidance
Osteoclast differentiation
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
Cholinergic synapse
Prion diseases
Pathogenic Escherichia coli infection
Measles
Viral myocarditishsa04012:ErbB signaling pathway
Central carbon metabolism in cancerhsa04064:NF-kappa B signaling pathway
HTLV-I infection
Primary immunodeficiencyhsa04520:Adherens junction
Tight junctionhsa04012:ErbB signaling pathway
NetPath Pathway IL2 Signaling PathwayNetPath_16:IL4 Signaling Pathway
EGFR1 Signaling PathwayNetPath_9:TNFalpha Signaling PathwayNetPath_23:TSH Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling PathwayNetPath_17:IL5 Signaling Pathway
PANTHER Pathway B cell activation
Parkinson disease
CCKR signaling map STP00012:Cadherin signaling pathway
EGF receptor signaling pathwayP00007:Axon guidance mediated by semaphorins
Cadherin signaling pathway
Integrin signalling pathway
Parkinson diseaseP00012:Cadherin signaling pathway
EGF receptor signaling pathwayP00049:Parkinson disease
T cell activationP00012:Cadherin signaling pathway
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
EGF receptor signaling pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
BCR signaling pathway
LPA receptor mediated events
GMCSF-mediated signaling events
Glypican 1 network
Signaling events mediated by PTP1B
Regulation of p38-alpha and p38-beta
Thromboxane A2 receptor signaling
CXCR4-mediated signaling events
IL5-mediated signaling events
Class I PI3K signaling events
amb2 Integrin signaling
EPHA forward signaling
PDGFR-beta signaling pathway
IL8- and CXCR2-mediated signaling events
Signaling events mediated by Stem cell factor receptor (c-Kit)
EPO signaling pathway
IL8- and CXCR1-mediated signaling events
Ephrin B reverse signaling
Alpha-synuclein signalinglysophospholipid_pathway:LPA receptor mediated events
Arf6 signaling events
Signaling events mediated by TCPTP
SHP2 signaling
Regulation of Telomerase
EGF receptor (ErbB1) signaling pathway
EGFR-dependent Endothelin signaling events
Posttranslational regulation of adherens junction stability and dissassembly
Direct p53 effectors
ErbB1 downstream signaling
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
E-cadherin signaling in keratinocytes
ErbB receptor signaling network
Internalization of ErbB1
Stabilization and expansion of the E-cadherin adherens junction
a6b1 and a6b4 Integrin signaling
Syndecan-3-mediated signaling eventsvegf_vegfr_pathway:VEGF and VEGFR signaling network
VEGFR3 signaling in lymphatic endotheliumfcer1pathway:Fc-epsilon receptor I signaling in mast cells
ErbB4 signaling events
TCR signaling in na&#xef
Ephrin A reverse signaling
Reelin signaling pathway
TCR signaling in na&#xef
Angiopoietin receptor Tie2-mediated signaling
Netrin-mediated signaling events
IL2-mediated signaling events
Nephrin/Neph1 signaling in the kidney podocyte
Signaling events mediated by VEGFR1 and VEGFR2
Syndecan-3-mediated signaling events
Alpha-synuclein signaling
Signaling events mediated by focal adhesion kinaseerbb4_pathway:ErbB4 signaling events
ErbB2/ErbB3 signaling events
Validated targets of C-MYC transcriptional repressionnfkappabatypicalpathway:Atypical NF-kappaB pathway
IL12-mediated signaling events
IL2 signaling events mediated by PI3K
IL2 signaling events mediated by STAT5
Alpha-synuclein signalingwnt_noncanonical_pathway:Noncanonical Wnt signaling pathway
CDC42 signaling events
Signaling events mediated by focal adhesion kinase
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast CellsPW000453:Fc Epsilon Receptor I Signaling in Mast CellsPW000168:Phosphatidylinositol Phosphate Metabolism
Reactome GPVI-mediated activation cascade
Regulation of KIT signaling
Cell surface interactions at the vascular wall
FCGR activation
PECAM1 interactions
Fc epsilon receptor (FCERI) signaling
EPH-Ephrin signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
FCERI mediated NF-kB activation
CD28 co-stimulation
CTLA4 inhibitory signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
Dectin-2 family
CD209 (DC-SIGN) signaling
Platelet Adhesion to exposed collagen
Regulation of signaling by CBL
Growth hormone receptor signaling
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-1236382:Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB2 events in EGFR signaling
GAB1 signalosome
SHC1 events in EGFR signaling
EGFR downregulation
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
EGFR Transactivation by Gastrin
Constitutive Signaling by Aberrant PI3K in Cancer
Constitutive Signaling by EGFRvIII
RAF/MAP kinase cascadeR-HSA-195399:VEGF binds to VEGFR leading to receptor dimerizationR-HSA-114604:GPVI-mediated activation cascade
DAP12 signaling
Nephrin interactions
NCAM signaling for neurite out-growth
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
CRMPs in Sema3A signaling
DCC mediated attractive signaling
Netrin mediated repulsion signals
VEGFA-VEGFR2 Pathway
RAF/MAP kinase cascade
Antigen activates B Cell Receptor (BCR) leading to generation of second messengersR-HSA-1250196:SHC1 events in ERBB2 signaling
Sema4D induced cell migration and growth-cone collapse
RAF/MAP kinase cascadeR-HSA-114604:GPVI-mediated activation cascade
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PD-1 signaling
Interleukin-2 signalingR-HSA-1433559:Regulation of KIT signaling
WikiPathways Kit receptor signaling pathway
IL-3 Signaling Pathway
Fc epsilon receptor (FCERI) signaling
Signaling by the B Cell Receptor (BCR)
Signaling by SCF-KIT
Growth hormone receptor signaling
B Cell Receptor Signaling Pathway
TSLP Signaling Pathway
RANKL/RANK Signaling Pathway
Platelet Adhesion to exposed collagen
GPVI-mediated activation cascade
Costimulation by the CD28 family
Cell surface interactions at the vascular wall
IL-5 Signaling PathwayWP673:ErbB Signaling Pathway
Regulation of Actin Cytoskeleton
EGF/EGFR Signaling Pathway
MAPK Signaling Pathway
Focal Adhesion
Aryl Hydrocarbon Receptor Pathway
Extracellular vesicle-mediated signaling in recipient cells
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Bladder Cancer
Hair Follicle Development: Induction (Part 1 of 3)
Signaling by ERBB4
Signaling by ERBB2
Gastrin-CREB signalling pathway via PKC and MAPK
PIP3 activates AKT signaling
Nanoparticle-mediated activation of receptor signaling
Aryl Hydrocarbon Receptor
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Gastric cancer network 2
AGE/RAGE pathway
Signaling Pathways in Glioblastoma
Arylhydrocarbon receptor (AhR) signaling pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
Integrated Breast Cancer Pathway
Signaling by EGFR
L1CAM interactionsWP1919:Signaling by VEGFWP69:TCR Signaling Pathway
Interferon type I signaling pathways
IL-2 Signaling Pathway
Ectoderm Differentiation
DAP12 interactions
Host Interactions of HIV factors
T-Cell Receptor and Co-stimulatory Signaling
Primary Focal Segmental Glomerulosclerosis FSGS
BDNF signaling pathway
Interleukin-11 Signaling Pathway
Pathogenic Escherichia coli infection
IL-7 Signaling Pathway
Leptin signaling pathway
Semaphorin interactions
Netrin-1 signaling
Nephrin interactions
NCAM signaling for neurite out-growth
Integrin-mediated Cell Adhesion
Cell surface interactions at the vascular wallWP710:DNA Damage Response (only ATM dependent)
ErbB Signaling Pathway
Semaphorin interactionsWP61:Notch Signaling Pathway
Inflammatory Response Pathway
TCR signaling
Costimulation by the CD28 familyWP2713:Signaling by SCF-KIT
Costimulation by the CD28 familyWP673:ErbB Signaling Pathway
EV release from cardiac cells and their functional effects
References
Ref 522319ClinicalTrials.gov (NCT00676299) A Safety and Dose-finding Study of JNJ-26483327, a Drug in Development for Cancer, for Patients With Advanced and/or Refractory Solid Malignancies.. U.S. National Institutes of Health.
Ref 550422National Cancer Institute Drug Dictionary (drug id 596693).
Ref 550423National Cancer Institute Drug Dictionary (drug id 596693).