TTD | Drug: D03BOZ

Drug General Information
Drug ID	D03BOZ
Former ID	DNC004074
Drug Name	RS-130830
Drug Type	Small molecular drug
Indication	HCV infection [ICD9: 070.4, 070.5, 070.70; ICD10:B17.1, B18.2]		Discontinued in Phase 2	[546851]
Formula	C19H20ClNO6S
Canonical SMILES	C1COCCC1(CS(=O)(=O)C2=CC=C(C=C2)OC3=CC=C(C=C3)Cl)C(=O)N<br />O
InChI	1S/C19H20ClNO6S/c20-14-1-3-15(4-2-14)27-16-5-7-17(8-6-16)28(24,25)13-19(18(22)21-23)9-11-26-12-10-19/h1-8,23H,9-13H2,(H,21,22)
InChIKey	ROSNVSQTEGHUKU-UHFFFAOYSA-N
PubChem Compound ID	3342298
Target and Pathway
Target(s)	Stromelysin-1	Target Info	Inhibitor	[527412]
	72 kDa type IV collagenase	Target Info	Inhibitor	[527412]
	MMP-9	Target Info	Inhibitor	[527412]
	Collagenase 3	Target Info	Inhibitor	[527412]
	Interstitial collagenase	Target Info	Inhibitor	[527412]
KEGG Pathway	TNF signaling pathway
	Transcriptional misregulation in cancer
	Rheumatoid arthritishsa04670:Leukocyte transendothelial migration
	GnRH signaling pathway
	Estrogen signaling pathway
	Pathways in cancer
	Proteoglycans in cancer
	Bladder cancerhsa04668:TNF signaling pathway
	Leukocyte transendothelial migration
	Hepatitis B
	MicroRNAs in cancer
	Bladder cancerhsa03320:PPAR signaling pathway
	Bladder cancer
	Rheumatoid arthritis
NetPath Pathway	IL1 Signaling Pathway
	IL4 Signaling PathwayNetPath_22:Leptin Signaling Pathway
	TCR Signaling Pathway
	ID Signaling PathwayNetPath_5:ID Signaling Pathway
	TWEAK Signaling Pathway
	Leptin Signaling Pathway
	TNFalpha Signaling PathwayNetPath_13:IL1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
	EGFR1 Signaling Pathway
	Wnt Signaling Pathway
PANTHER Pathway	Plasminogen activating cascade
	CCKR signaling map STP00004:Alzheimer disease-presenilin pathwayP00004:Alzheimer disease-presenilin pathway
	CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
	Plasminogen activating cascadeP00004:Alzheimer disease-presenilin pathway
Pathway Interaction Database	Posttranslational regulation of adherens junction stability and dissassembly
	p75(NTR)-mediated signaling
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalinglysophospholipid_pathway:LPA receptor mediated events
	Plasma membrane estrogen receptor signaling
	Osteopontin-mediated events
	Validated transcriptional targets of AP1 family members Fra1 and Fra2
	Angiopoietin receptor Tie2-mediated signaling
	Direct p53 effectors
	amb2 Integrin signaling
	ATF-2 transcription factor network
	FOXM1 transcription factor network
	Regulation of nuclear beta catenin signaling and target gene transcription
	Syndecan-2-mediated signaling eventslysophospholipid_pathway:LPA receptor mediated events
	Validated targets of C-MYC transcriptional activation
	CXCR4-mediated signaling events
	Syndecan-4-mediated signaling events
	AP-1 transcription factor network
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	Syndecan-1-mediated signaling events
	FGF signaling pathwayupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingendothelinpathway:Endothelins
	Glucocorticoid receptor regulatory network
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Assembly of collagen fibrils and other multimeric structures
	EGFR Transactivation by GastrinR-HSA-1442490:Collagen degradation
	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
	EPH-ephrin mediated repulsion of cellsR-HSA-1442490:Collagen degradation
	Assembly of collagen fibrils and other multimeric structuresR-HSA-1442490:Collagen degradation
	Basigin interactions
WikiPathways	Activation of Matrix Metalloproteinases
	Gastrin-CREB signalling pathway via PKC and MAPK
	Oncostatin M Signaling Pathway
	Matrix MetalloproteinasesWP2769:Activation of Matrix Metalloproteinases
	AGE/RAGE pathway
	Matrix MetalloproteinasesWP474:Endochondral Ossification
	IL1 and megakaryotyces in obesity
	Mammary gland development pathway - Involution (Stage 4 of 4)
	Degradation of collagen
	Spinal Cord Injury
	TWEAK Signaling Pathway
	Angiogenesis
	Osteopontin Signaling
	Matrix MetalloproteinasesWP366:TGF beta Signaling Pathway
	Bladder Cancer
	Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
	Prostate Cancer
	Integrated Breast Cancer Pathway
	Integrated Cancer pathway
	Cell surface interactions at the vascular wall
	Matrix Metalloproteinases
References
Ref 546851	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010620)
Ref 527412	Bioorg Med Chem Lett. 2005 Feb 15;15(4):1101-6.Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13).

Drug Information