Drug Information

Drug General Information
Drug ID
D02YVM
Former ID
DNCL003136
Drug Name
Zicronapine
Drug Type
Small molecular drug
Indication Schizophrenia [ICD9: 295; ICD10:F20] Phase 3 [523357]
Company
Lundbeck
Formula
C22H27ClN2
Canonical SMILES
CC1(CN(CCN1C)C2CC(C3=C2C=C(C=C3)Cl)C4=CC=CC=C4)C
InChI
1S/C22H27ClN2/c1-22(2)15-25(12-11-24(22)3)21-14-19(16-7-5-4-6-8-16)18-10-9-17(23)13-20(18)21/h4-10,13,19,21H,11-12,14-15H2,1-3H3/t19-,21+/m0/s1
InChIKey
BYPMJBXPNZMNQD-PZJWPPBQSA-N
CAS Number
CAS 170381-16-5
PubChem Compound ID
11465618
PubChem Substance ID
16676298, 23603796, 42544573, 79419855, 135266807, 140419785, 163312359, 174494660, 198975150, 227170595, 244101005
Target and Pathway
Target(s) D(2) dopamine receptor Target Info Modulator [549861]
Dopamine D1 receptor Target Info Modulator [549861]
5-hydroxytryptamine 2A receptor Target Info Modulator [549861]
KEGG Pathway Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Alcoholismhsa04020:Calcium signaling pathway
Amphetamine addiction
Morphine addiction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Dopamine receptor mediated signaling pathway
Nicotine pharmacodynamics pathwayP05912:Dopamine receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
PathWhiz Pathway Dopamine Activation of Neurological Reward System
Reactome Dopamine receptors
G alpha (i) signalling eventsR-HSA-390651:Dopamine receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Hypothetical Network for Drug Addiction
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Genes and (Common) Pathways Underlying Drug Addiction
GPCR ligand binding
GPCR downstream signaling
Nicotine Activity on Dopaminergic NeuronsWP666:Hypothetical Network for Drug Addiction
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
GPCRs, Other
References
Ref 523357ClinicalTrials.gov (NCT01295372) Safety and Efficacy of Zicronapine in Patients With Schizophrenia. U.S. National Institutes of Health.
Ref 549861Clinical pipeline report, company report or official report of Lundbeck.