TTD | Drug: D0X7VM

Drug General Information
Drug ID	D0X7VM
Former ID	DNC007829
Drug Name	KYS-05090
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529566]
Formula	C37H43N5O
Canonical SMILES	CN(C)CCCCCN(C)C1=NC2=CC=CC=C2C(N1C3=CC=C(C=C3)C4=CC=CC=<br />C4)CC(=O)NCC5=CC=CC=C5
InChI	1S/C37H43N5O/c1-40(2)25-13-6-14-26-41(3)37-39-34-20-12-11-19-33(34)35(27-36(43)38-28-29-15-7-4-8-16-29)42(37)32-23-21-31(22-24-32)30-17-9-5-10-18-30/h4-5,7-12,15-24,35H,6,13-14,25-28H2,1-3H3,(H,38,43)
InChIKey	QVXCZTNUVKNCGU-UHFFFAOYSA-N
PubChem Compound ID	23661603
Target and Pathway
Target(s)	Voltage-dependent N-type calcium channel	Target Info	Inhibitor	[529044]
Target(s)	Voltage-dependent T-type calcium channel alpha-1G subunit	Target Info	Inhibitor	[529566]
KEGG Pathway	MAPK signaling pathway
	Calcium signaling pathway
	Synaptic vesicle cycle
	Retrograde endocannabinoid signaling
	Cholinergic synapse
	Serotonergic synapse
	GABAergic synapse
	Dopaminergic synapse
	Taste transduction
	Type II diabetes mellitus
	Morphine addiction
	Nicotine addictionhsa04010:MAPK signaling pathway
	Circadian entrainment
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group II pathway
	Thyrotropin-releasing hormone receptor signaling pathway
	Endogenous cannabinoid signaling
	GABA-B receptor II signalingP05730:Endogenous cannabinoid signaling
	GABA-B receptor II signaling
	Nicotine pharmacodynamics pathway
Pathway Interaction Database	Regulation of nuclear beta catenin signaling and target gene transcription
PathWhiz Pathway	Muscle/Heart Contraction
Reactome	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium ChannelsR-HSA-419037:NCAM1 interactions
WikiPathways	Calcium Regulation in the Cardiac Cell
	Synaptic Vesicle PathwayWP1866:NCAM signaling for neurite out-growth
	Nicotine Activity on Chromaffin Cells
References
Ref 529566	Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. Epub 2008 Jun 14.T-type Ca2+ channel blockers suppress the growth of human cancer cells.
Ref 529044	Bioorg Med Chem Lett. 2007 Nov 1;17(21):5740-3. Epub 2007 Sep 1.Discovery of potent T-type calcium channel blocker.
Ref 529566	Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. Epub 2008 Jun 14.T-type Ca2+ channel blockers suppress the growth of human cancer cells.

Drug Information