Drug Information

Drug General Information
Drug ID
D0FA6S
Former ID
DIB002760
Drug Name
Altiratinib
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [549538]
Company
Deciphera pharmaceuticals
Target and Pathway
Target(s) Vascular endothelial growth factor receptor 2 Target Info Antagonist [550598]
Angiopoietin 1 receptor Target Info Inhibitor [550598]
Hepatocyte growth factor receptor Target Info Inhibitor [550598]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
Endocytosis
PI3K-Akt signaling pathway
VEGF signaling pathway
Focal adhesion
Proteoglycans in cancerhsa04014:Ras signaling pathway
HIF-1 signaling pathway
Rheumatoid arthritishsa04014:Ras signaling pathway
Axon guidance
Adherens junction
Bacterial invasion of epithelial cells
Epithelial cell signaling in Helicobacter pylori infection
Malaria
Pathways in cancer
Transcriptional misregulation in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Melanoma
Central carbon metabolism in cancer
NetPath Pathway IL2 Signaling PathwayNetPath_8:Wnt Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathwayP00005:Angiogenesis
Pathway Interaction Database HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
Signaling events mediated by TCPTP
SHP2 signaling
S1P1 pathway
VEGF and VEGFR signaling network
Integrins in angiogenesis
Signaling events mediated by VEGFR1 and VEGFR2
Notch-mediated HES/HEY networkangiopoietinreceptor_pathway:Angiopoietin receptor Tie2-mediated signaling
SHP2 signalingmet_pathway:Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
Arf6 signaling events
Posttranslational regulation of adherens junction stability and dissassembly
Direct p53 effectors
Syndecan-1-mediated signaling events
Stabilization and expansion of the E-cadherin adherens junction
a6b1 and a6b4 Integrin signaling
FGF signaling pathway
Regulation of retinoblastoma protein
Reactome Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Integrin cell surface interactions
EPHA-mediated growth cone collapse
VEGFA-VEGFR2 Pathway
VEGFR2 mediated cell proliferationR-HSA-210993:Tie2 Signaling
RAF/MAP kinase cascadeR-HSA-416550:Sema4D mediated inhibition of cell attachment and migration
WikiPathways Focal Adhesion
Nifedipine Activity
Cardiac Progenitor Differentiation
Signaling by VEGF
AngiogenesisWP363:Wnt Signaling Pathway Netpath
Cell surface interactions at the vascular wall
AngiogenesisWP366:TGF beta Signaling Pathway
Signaling of Hepatocyte Growth Factor Receptor
Extracellular vesicle-mediated signaling in recipient cells
Signaling Pathways in Glioblastoma
miR-targeted genes in squamous cell - TarBase
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
Semaphorin interactions
References
Ref 549538Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800040094)
Ref 550598Clinical pipeline report, company report or official report of Deciphera Pharmaceuticals.