Drug Information

Drug General Information
Drug ID
D00SOZ
Former ID
DIB001660
Drug Name
DE-117
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Phase 2 [524813]
Target and Pathway
Target(s) Prostaglandin E2receptor, EP2 subtype Target Info Agonist [551625]
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
Renin secretion
Pathways in cancer
Reactome Prostanoid ligand receptors
G alpha (s) signalling events
WikiPathways Prostaglandin Synthesis and Regulation
GPCRs, Class A Rhodopsin-like
Ovarian Infertility Genes
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 524813ClinicalTrials.gov (NCT02179008) Multi-center Phase II Study Assessing the Safety and Efficacy of DE-117 Ophthalmic Solution in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension. U.S. National Institutes of Health.
Ref 551625Clinical pipeline report, company report or official report of Santen Pharmaceutical.