Drug Information

Drug General Information
Drug ID
D0A1GR
Former ID
DIB008810
Drug Name
CALAA-01
Synonyms
Ribonucleotide reductase M2 subunit (RRM2)-targeted siRNA agent (RONDEL, intravenous, cancer), Calando
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Phase 1 [522336]
Company
Calando pharmaceuticals
Target and Pathway
Target(s) Ribonucleoside-diphosphatereductase subunit M2 Target Info Modulator [1572591]
Transferrin Target Info Modulator [1572591]
BioCyc Pathway Pyrimidine deoxyribonucleotides biosynthesis from CTP
Pyrimidine deoxyribonucleotides de novo biosynthesis
Guanosine nucleotides de novo biosynthesis
Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
Superpathway of purine nucleotide salvage
Purine nucleotides de novo biosynthesis
Adenosine deoxyribonucleotides de novo biosynthesis
Guanosine deoxyribonucleotides de novo biosynthesis
KEGG Pathway Purine metabolism
Pyrimidine metabolism
Glutathione metabolism
Metabolic pathways
p53 signaling pathwayhsa04066:HIF-1 signaling pathway
Mineral absorption
NetPath Pathway EGFR1 Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
PANTHER Pathway p53 pathway
De novo purine biosynthesis
De novo pyrimidine deoxyribonucleotide biosynthesis
Pathway Interaction Database E2F transcription factor networkephbfwdpathway:EPHB forward signaling
HIF-1-alpha transcription factor network
PathWhiz Pathway Purine Metabolism
Pyrimidine Metabolism
Reactome E2F mediated regulation of DNA replication
G1/S-Specific TranscriptionR-HSA-114608:Platelet degranulation
Iron uptake and transport
Transferrin endocytosis and recycling
WikiPathways Nucleotide Metabolism
Retinoblastoma (RB) in Cancer
Metabolism of nucleotides
Fluoropyrimidine ActivityWP706:SIDS Susceptibility Pathways
Differentiation Pathway
Iron uptake and transport
Iron metabolism in placenta
References
Ref 522336ClinicalTrials.gov (NCT00689065) Safety Study of CALAA-01 to Treat Solid Tumor Cancers. U.S. National Institutes of Health.
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.