Drug Information

Drug General Information
Drug ID
D02XLI
Former ID
DIB003325
Drug Name
LY-2979165
Synonyms
Bipolar disorder therapy, Eli Lilly
Indication Bipolar disorder [ICD9: 296.0, 296.1, 296.4, 296.5, 296.6, 296.7, 296.8, 300; ICD10:F31, F40-F42] Discontinued in Phase 1 [523787]
Company
Eli Lilly & Co
Target and Pathway
Target(s) Metabotropic glutamate receptor 2 Target Info Modulator [551839]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapse
Cocaine addiction
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group II pathway
Reactome G alpha (i) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways GPCRs, Class C Metabotropic glutamate, pheromone
GPCR ligand binding
GPCR downstream signaling
References
Ref 523787ClinicalTrials.gov (NCT01524237) A Study of LY2979165 and LY2140023 in Healthy Volunteers. U.S. National Institutes of Health.
Ref 551839Annual Reports in Medicinal Chemistry. Volume 47, 2012, Page(78).