Drug Information

Drug General Information
Drug ID
D0UL7L
Former ID
DIB012525
Drug Name
Recombinant human Erbb3 fragment therapeutic tumor vaccine
Synonyms
Fragment therapeutic tumor vaccine; Recombinant human Erbb3 fragment therapeutic tumor vaccine (injectable, Erbb2-overexpressing cancer)
Drug Type
Vaccine
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 1 [551788]
Company
Zensun (Shanghai) Sci-Tech Co Ltd
Target and Pathway
Target(s) Receptor protein-tyrosine kinase erbB-3 Target Info [551787]
Receptor protein-tyrosine kinase erbB-2 Target Info [551787]
KEGG Pathway ErbB signaling pathway
Calcium signaling pathway
Endocytosis
Proteoglycans in cancer
MicroRNAs in cancerhsa04012:ErbB signaling pathway
HIF-1 signaling pathway
Focal adhesion
Adherens junction
Pathways in cancer
MicroRNAs in cancer
Pancreatic cancer
Endometrial cancer
Prostate cancer
Bladder cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
NetPath Pathway TNFalpha Signaling PathwayNetPath_11:TCR Signaling Pathway
PANTHER Pathway Cadherin signaling pathway
EGF receptor signaling pathwayP00012:Cadherin signaling pathway
EGF receptor signaling pathway
Pathway Interaction Database ErbB2/ErbB3 signaling events
ErbB receptor signaling network
a6b1 and a6b4 Integrin signalingerbb4_pathway:ErbB4 signaling events
a6b1 and a6b4 Integrin signaling
Validated targets of C-MYC transcriptional repression
PathWhiz Pathway Phosphatidylinositol Phosphate Metabolism
Reactome SHC1 events in ERBB2 signaling
PLCG1 events in ERBB2 signaling
PIP3 activates AKT signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
Constitutive Signaling by Aberrant PI3K in Cancer
Sema4D induced cell migration and growth-cone collapse
RAF/MAP kinase cascade
WikiPathways ErbB Signaling Pathway
Apoptosis-related network due to altered Notch3 in ovarian cancer
Signaling Pathways in Glioblastoma
miR-targeted genes in muscle cell - TarBase
Heart DevelopmentWP710:DNA Damage Response (only ATM dependent)
EGF/EGFR Signaling Pathway
Focal Adhesion
Extracellular vesicle-mediated signaling in recipient cells
Bladder Cancer
Signaling by ERBB2
Integrated Pancreatic Cancer Pathway
Leptin signaling pathway
Semaphorin interactions
References
Ref 551788Clinical pipeline report, company report or official report of Zensun.
Ref 551787Clinical pipeline report, company report or official report of Zensun.