TTD | Drug: D05KZK

Drug General Information
Drug ID	D05KZK
Former ID	DIB009673
Drug Name	SMT-D002
Synonyms	Oxybutynin chloride; DL-06003
Indication	Seborrhea [ICD10:L21]		Approved	[551707]
Company	DanioLabs Ltd
Canonical SMILES	Cl.CCN(CC)CC#CCOC(=O)C(O)(C1CCCCC1)c2ccccc2
InChI	1S/C22H31NO3.ClH/c1-3-23(4-2)17-11-12-18-26-21(24)22(25,19-13-7-5-8-14-19)20-15-9-6-10-16-20;/h5,7-8,13-14,20,25H,3-4,6,9-10,15-18H2,1-2H3;1H
InChIKey	SWIJYDAEGSIQPZ-UHFFFAOYSA-N
Target and Pathway
Target(s)	Muscarinic acetylcholine receptor M3	Target Info	Agonist	[527286]
	Muscarinic acetylcholine receptor M1	Target Info	Agonist	[527286]
	Muscarinic acetylcholine receptor M2	Target Info	Agonist	[527286]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Cholinergic synapse
	Regulation of actin cytoskeleton
	Insulin secretion
	Salivary secretion
	Gastric acid secretion
	Pancreatic secretionhsa04020:Calcium signaling pathway
	cAMP signaling pathway
	PI3K-Akt signaling pathway
	Regulation of actin cytoskeletonhsa04020:Calcium signaling pathway
PANTHER Pathway	Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway
	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
PathWhiz Pathway	Gastric Acid ProductionPW000564:Muscle/Heart Contraction
Reactome	Muscarinic acetylcholine receptors
	Acetylcholine regulates insulin secretion
	G alpha (q) signalling eventsR-HSA-390648:Muscarinic acetylcholine receptors
	G alpha (i) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	Regulation of Actin Cytoskeleton
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Integration of energy metabolism
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, OtherWP58:Monoamine GPCRs
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR downstream signalingWP706:SIDS Susceptibility Pathways
	GPCRs, Other
References
Ref 551707	Clinical pipeline report, company report or official report of Summit.
Ref 527286	Demonstration of bladder selective muscarinic receptor binding by intravesical oxybutynin to treat overactive bladder. J Urol. 2004 Nov;172(5 Pt 1):2059-64.

Drug Information