Drug Information

Drug General Information
Drug ID
D0K3SM
Former ID
DIB010765
Drug Name
MALP-2S
Indication Pancreatic cancer [ICD9: 140-199, 140-229, 157, 210-229; ICD10:C25] Phase 1/2 [528971]
Company
MBiotec GmbH
Target and Pathway
Target(s) Toll-like receptor 6 Target Info Modulator [531307]
Toll-like receptor 2 Target Info Modulator [531307]
KEGG Pathway Phagosome
Toll-like receptor signaling pathway
Chagas disease (American trypanosomiasis)
Tuberculosishsa04145:Phagosome
PI3K-Akt signaling pathway
Legionellosis
Leishmaniasis
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
Measles
Herpes simplex infection
Proteoglycans in cancer
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
NetPath Pathway IL5 Signaling Pathway
IL2 Signaling Pathway
TCR Signaling PathwayNetPath_16:IL4 Signaling Pathway
TCR Signaling Pathway
PANTHER Pathway Toll receptor signaling pathwayP00054:Toll receptor signaling pathway
Pathway Interaction Database Endogenous TLR signalingtoll_endogenous_pathway:Endogenous TLR signaling
Reactome MyD88:Mal cascade initiated on plasma membrane
Toll Like Receptor TLR6:TLR2 Cascade
MyD88 deficiency (TLR2/4)
IRAK4 deficiency (TLR2/4)R-HSA-1461957:Beta defensins
IRAK4 deficiency (TLR2/4)
WikiPathways Toll-like receptor signaling pathway
Toll-Like Receptors Cascades
MyD88:Mal cascade initiated on plasma membrane
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
IL1 and megakaryotyces in obesity
Human Complement System
Defensins
Regulation of toll-like receptor signaling pathway
References
Ref 528971Intratumoural injection of the toll-like receptor-2/6 agonist 'macrophage-activating lipopeptide-2' in patients with pancreatic carcinoma: a phase I/II trial. Br J Cancer. 2007 Sep 3;97(5):598-604. Epub 2007 Jul 31.
Ref 531307Failure of mycoplasma lipoprotein MALP-2 to induce NK cell activation through dendritic cell TLR2. Microbes Infect. 2011 Apr;13(4):350-8.