TTD | Drug: D0T5JS

Drug General Information
Drug ID	D0T5JS
Former ID	DIB009475
Drug Name	TT-100
Synonyms	TT-100, TriAct; Dual IGF-1/EGFR inhibitor (non-small-cell lung cancer), TriAct
Indication	Non-small cell lung cancer [ICD10:C33-C34]		Phase 2	[548064]
Company	TriAct Therapeutics
Target and Pathway
Target(s)	Epidermal growth factor receptor	Target Info	Inhibitor	[549834]
Target(s)	Insulin-like growth factor I receptor	Target Info	Inhibitor	[549834]
KEGG Pathway	MAPK signaling pathway
	ErbB signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	Calcium signaling pathway
	Cytokine-cytokine receptor interaction
	HIF-1 signaling pathway
	FoxO signaling pathway
	Endocytosis
	PI3K-Akt signaling pathway
	Dorso-ventral axis formation
	Focal adhesion
	Adherens junction
	Gap junction
	Regulation of actin cytoskeleton
	GnRH signaling pathway
	Estrogen signaling pathway
	Oxytocin signaling pathway
	Epithelial cell signaling in Helicobacter pylori infection
	Hepatitis C
	Pathways in cancer
	Proteoglycans in cancer
	MicroRNAs in cancer
	Pancreatic cancer
	Endometrial cancer
	Glioma
	Prostate cancer
	Melanoma
	Bladder cancer
	Non-small cell lung cancer
	Central carbon metabolism in cancer
	Choline metabolism in cancerhsa04014:Ras signaling pathway
	Oocyte meiosis
	AMPK signaling pathway
	Signaling pathways regulating pluripotency of stem cells
	Long-term depression
	Ovarian steroidogenesis
	Progesterone-mediated oocyte maturation
	Transcriptional misregulation in cancer
NetPath Pathway	IL4 Signaling Pathway
NetPath Pathway	EGFR1 Signaling Pathway
PANTHER Pathway	Cadherin signaling pathway
	EGF receptor signaling pathwayP00032:Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
	Insulin/IGF pathway-protein kinase B signaling cascade
Pathway Interaction Database	LPA receptor mediated events
	Signaling events mediated by PTP1B
	Arf6 signaling events
	Signaling events mediated by TCPTP
	Thromboxane A2 receptor signaling
	SHP2 signaling
	Regulation of Telomerase
	EGF receptor (ErbB1) signaling pathway
	EGFR-dependent Endothelin signaling events
	Posttranslational regulation of adherens junction stability and dissassembly
	Direct p53 effectors
	ErbB1 downstream signaling
	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	E-cadherin signaling in keratinocytes
	ErbB receptor signaling network
	Internalization of ErbB1
	Stabilization and expansion of the E-cadherin adherens junction
	a6b1 and a6b4 Integrin signaling
	Syndecan-3-mediated signaling eventser_nongenomic_pathway:Plasma membrane estrogen receptor signaling
	IGF1 pathway
	Integrins in angiogenesis
Reactome	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
	SHC1 events in ERBB2 signaling
	PLCG1 events in ERBB2 signaling
	PIP3 activates AKT signaling
	GRB2 events in EGFR signaling
	GAB1 signalosome
	SHC1 events in EGFR signaling
	EGFR downregulation
	GRB2 events in ERBB2 signaling
	PI3K events in ERBB2 signaling
	EGFR Transactivation by Gastrin
	Constitutive Signaling by Aberrant PI3K in Cancer
	Constitutive Signaling by EGFRvIII
	RAF/MAP kinase cascadeR-HSA-2428928:IRS-related events triggered by IGF1R
	SHC-related events triggered by IGF1R
WikiPathways	ErbB Signaling Pathway
	Regulation of Actin Cytoskeleton
	EGF/EGFR Signaling Pathway
	MAPK Signaling Pathway
	Focal Adhesion
	Aryl Hydrocarbon Receptor Pathway
	Extracellular vesicle-mediated signaling in recipient cells
	TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
	Bladder Cancer
	Hair Follicle Development: Induction (Part 1 of 3)
	Signaling by ERBB4
	Signaling by ERBB2
	Gastrin-CREB signalling pathway via PKC and MAPK
	PIP3 activates AKT signaling
	Nanoparticle-mediated activation of receptor signaling
	Aryl Hydrocarbon Receptor
	Spinal Cord Injury
	Integrated Pancreatic Cancer Pathway
	Gastric cancer network 2
	AGE/RAGE pathway
	Signaling Pathways in Glioblastoma
	Arylhydrocarbon receptor (AhR) signaling pathway
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	Integrated Breast Cancer Pathway
	Signaling by EGFR
	L1CAM interactionsWP615:Senescence and Autophagy in Cancer
	Insulin Signaling
	Endochondral Ossification
	Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
	Apoptosis
	TSH signaling pathway
	MicroRNAs in cardiomyocyte hypertrophy
References
Ref 548064	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021633)
Ref 549834	BiPar Sciences Co-founder Reunites Management Team At TriAct Therapeutics to Advance Clinical Stage Cancer Programs. TriAct Therapeutics. Sept. 10, 2009.

Drug Information