Drug Information

Drug General Information
Drug ID
D0DH5X
Former ID
DNCL003828
Drug Name
MK-4618
Indication Overactive bladder disorder [ICD9: 188, 596.51; ICD10:C67, N32.81] Phase 2 [523395]
Company
Merck
Target and Pathway
Target(s) Beta-3 adrenergic receptor Target Info Agonist [549065]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Salivary secretion
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta3 adrenergic receptor signaling pathway
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 523395ClinicalTrials.gov (NCT01314872) A Study of the Efficacy and Safety of MK-4618 in Patients With Overactive Bladder (OAB) (MK-4618-008 AM3 EXT1[AM2]). U.S. National Institutes of Health.
Ref 549065Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800031896)