Target General Information
Target ID T73992
Target Name Beta-secretase
Synonyms BACE1; ASP2; Aspartyl protease 2; BACE; Beta-site AbetaPP-cleaving enzyme; Beta-site amyloid precursor protein cleaving enzyme; Memapsin-2; Membrane-associated aspartic protease 2; Transmembrane aspartic protease
Target Type Clinical Trial
Gene Name BACE1
Biochemical Class Peptidase
UniProt ID BACE1_HUMAN||BACE2_HUMAN
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 532395AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice. J Neurosci. 2013 Jun 12;33(24):10075-84.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.