Target expression details

Target General Information
Target ID T99840
Target Name Gamma-secretase
Synonyms APH; Aph-1beta; PSFL; Presenilin-stabilization factor-like
Target Type Clinical Trial
Gene Name APH1A
Biochemical Class APH-1 family
UniProt ID APH1A_HUMAN||APH1B_HUMAN||NICA_HUMAN||PEN2_HUMAN||PSN1_HUMAN
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref
Ref 542361(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7338).
Ref 542711(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7746).
Ref 531882Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors. J Clin Oncol. 2012 Jul 1;30(19):2348-53.
Ref 525008ClinicalTrials.gov (NCT02299635) A Study Evaluating PF-03084014 In Patients With Advanced Breast Cancer With Or Without Notch Alterations. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.