Target Information

Target General Infomation
Target ID
T34204
Former ID
TTDI03121
Target Name
CNGA2
Gene Name
CNGA2
Synonyms
CNGA2
Target Type
Clinical Trial
Disease Myeloneuropathy [ICD10: G04.1]
UniProt ID
Q16280
Sequence
MTEKTNGVKSSPANNHNHHAPPAIKANGKDDHRTSSRPHSAADDDTSSELQRLADVDAPQ
QGRSGFRRIVRLVGIIREWANKNFREEEPRPDSFLERFRGPELQTVTTQEGDGKGDKDGE
DKGTKKKFELFVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDY
VSDVVYIADLFIRLRTGFLEQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDI
HSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYYAISKSI
GFGVDTWVYPNITDPEYGYLAREYIYCLYWSTLTLTTIGETPPPVKDEEYLFVIFDFLIG
VLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEAKVIRWFDYLWTNK
KTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELVLKLRPQVFSPGDY
ICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNIKGSKMGNRRTANI
RSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEGLLDENEVATSMEVDVQEK
LGQLETNMETLYTRFGRLLAEYTGAQQKLKQRITVLETKMKQNNEDDYLSDGMNSPELAA
ADEP
Drugs and Mode of Action
Drug(s) dequalinium Drug Info Clinical trial Myeloneuropathy [526067]
Inhibitor (gating inhibitor) all-trans-retinal Drug Info [526344]
PIP3 Drug Info [528468]
Blocker (channel blocker) dequalinium Drug Info [526973]
L-(cis)-diltiazem Drug Info [528435]
References
Ref 526067Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines. Neuropharmacology. 2001 May;40(6):772-83.
Ref 526344All-trans-retinal shuts down rod cyclic nucleotide-gated ion channels: a novel role for photoreceptor retinoids in the response to bright light. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8372-7. Epub 2002 May 28.
Ref 526973State-dependent block of CNG channels by dequalinium. J Gen Physiol. 2004 Mar;123(3):295-304.
Ref 528435Primary structure and functional expression of a cyclic nucleotide-activated channel from olfactory neurons. Nature. 1990 Sep 13;347(6289):184-7.
Ref 528468Interplay between PIP3 and calmodulin regulation of olfactory cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15635-40. Epub 2006 Oct 10.