Target Information

Target General Infomation
Target ID
T70539
Former ID
TTDR00612
Target Name
Melanin-concentrating hormone receptor 2
Gene Name
MCHR2
Synonyms
G protein coupled receptor 145; GPRv17; MCH receptor 2; MCH(2) receptor; MCH-2R; MCH-R2; MCH2; MCH2R; MCHR-2; MCHR2
Target Type
Research
Function
Receptor for melanin-concentrating hormone, coupled to G proteins that activate phosphoinositide hydrolysis.
BioChemical Class
GPCR rhodopsin
UniProt ID
Q969V1
Sequence
MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTII
RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFAC
SAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDG
VESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPS
VPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSS
INPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
Antagonist ATC0065 Drug Info [527402]
compound 38 Drug Info [531717]
Agonist melanin-concentrating hormone Drug Info [526079]
Pathways
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
G alpha (i) signalling events
WikiPathways Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 526079Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7564-9. Epub 2001 Jun 12.
Ref 527402Anxiolytic- and antidepressant-like profile of ATC0065 and ATC0175: nonpeptidic and orally active melanin-concentrating hormone receptor 1 antagonists. J Pharmacol Exp Ther. 2005 May;313(2):831-9. Epub 2005 Jan 26.
Ref 531717Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2. Bioorg Med Chem Lett. 2012 Jan 1;22(1):363-6.