Details of Disease

General Information of Disease (ID: DIS1CYA2)

• Disease Name: Convulsion
• Disease Class: 8A61-8A6Z: Epilepsy/seizure
• Definition: Disorders characterized by recurrent TICS that may interfere with speech and other activities. Tics are sudden, rapid, nonrhythmic, stereotyped motor movements or vocalizations which may be exacerbated by stress and are generally attenuated during absorbing activities. Tic disorders are distinguished from conditions which feature other types of abnormal movements that may accompany another another condition. (From DSM-IV, 1994)
• Disease Hierarchy:
  DISLR2HH: Specific developmental disorder
  DIS1CYA2: Convulsion
• ICD Code:
  ICD-11: ICD-11: 8A68.Z
  ICD-9: ICD-9: 780.3
  Expand ICD-11: '8A68.Z
  Expand ICD-9: 780.3
• Disease Identifiers:
  MONDO ID: MONDO_0002420
  UMLS CUI: C2169806
  MedGen ID: 853666
  HPO ID: HP:0100033

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 2 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Anidulafungin	DM8QM5U	Approved	Small molecular drug	[1]
Lacosamide	DMVM6QR	Approved	Small molecular drug	[2]

This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
CI-966	DM8T2KA	Phase 1	Small molecular drug	[3]
GP-3269	DM035LO	Phase 1	NA	[4]

This Disease is Treated as An Indication in 3 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
YM-90K	DMWRT4L	Discontinued in Phase 2	Small molecular drug	[5]
Imepitoin	DM8OYZB	Discontinued in Phase 1	Small molecular drug	[6]
SORETOLIDE	DMTDLHG	Terminated	Small molecular drug	[7]

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
HCN4	TTQP04A	Strong	Genetic Variation	[8]
PRKCI	TTWJTHX	Strong	Biomarker	[9]

This Disease Is Related to 4 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
GNA13	OTVDL515	Limited	Biomarker	[10]
ECT2	OTQDUCT6	Strong	Biomarker	[9]
KCNE1	OTZNQUW9	Strong	Genetic Variation	[8]
PNKD	OT6G9UXN	Strong	Biomarker	[11]

References

• [1] Echinocandins: pharmacokinetic and therapeutic issues. Curr Med Res Opin. 2009 Jul;25(7):1741-50.
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7472).
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4612).
• [4] Adenosine kinase inhibitors. 6. Synthesis, water solubility, and antinociceptive activity of 5-phenyl-7-(5-deoxy-beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidines substituted at C4 with glycinamides andrelated compounds. J Med Chem. 2005 Dec 1;48(24):7808-20.
• [5] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002155)
• [6] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008368)
• [7] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002789)
• [8] The C-terminal HCN4 variant P883R alters channel properties and acts as genetic modifier of atrial fibrillation and structural heart disease.Biochem Biophys Res Commun. 2019 Oct 29;519(1):141-147. doi: 10.1016/j.bbrc.2019.08.150. Epub 2019 Aug 31.
• [9] PKC maintains a tumor-initiating cell phenotype that is required for ovarian tumorigenesis.Mol Cancer Res. 2013 Dec;11(12):1624-35. doi: 10.1158/1541-7786.MCR-13-0371-T. Epub 2013 Oct 30.
• [10] GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers.Oncogene. 2018 Mar;37(10):1340-1353. doi: 10.1038/s41388-017-0038-6. Epub 2017 Dec 19.
• [11] The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family. Mol Psychiatry. 2018 Jun;23(6):1487-1495. doi: 10.1038/mp.2017.179. Epub 2017 Sep 12.