Details of Disease

General Information of Disease (ID: DIS3UA8E)

Disease Name	Hemorrhagic cystitis
Disease Class	GC00: Cystitis
Definition	Inflammation of the bladder resulting in bloody urine.
Disease Hierarchy	DIS2D4B9: Cystitis DIS3UA8E: Hemorrhagic cystitis
ICD Code	ICD-11 ICD-11: GC00.1
Disease Identifiers	MONDO ID MONDO_0000496 MESH ID D000096722 UMLS CUI C0085692 MedGen ID 508360 SNOMED CT ID 87696004

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Posoleucel	DMFY63O	Phase 3	Cell therapy	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
GSR	TTEP6RV	Disputed	Biomarker	[2]
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This Disease Is Related to 2 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
ALDH3A1	OTAYZZE6	moderate	Genetic Variation	[3]
HCST	OTILCB4K	Strong	Biomarker	[4]
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References

1	ClinicalTrials.gov (NCT04390113) Phase 3 Multicenter, Double-Blind, Placebo-Controlled Trial of Viralym-M (ALVR105) for the Treatment of Patients With Virus-Associated Hemorrhagic Cystitis After Allogeneic Hematopoietic Cell Transplant (HCT). U.S.National Institutes of Health.
2	Protective effect of aminoguanidine against oxidative stress and bladder injury in cyclophosphamide-induced hemorrhagic cystitis in rat.Cell Biochem Funct. 2009 Jan;27(1):56-62. doi: 10.1002/cbf.1534.
3	Relations between polymorphisms in drug-metabolising enzymes and toxicity of chemotherapy with cyclophosphamide, thiotepa and carboplatin. Pharmacogenet Genomics. 2008 Nov;18(11):1009-15. doi: 10.1097/FPC.0b013e328313aaa4.
4	Intravesicular cidofovir for BK hemorrhagic cystitis in pediatric patients after hematopoietic stem cell transplant.Pediatr Transplant. 2018 May;22(3):e13141. doi: 10.1111/petr.13141. Epub 2018 Feb 1.