Details of Disease

General Information of Disease (ID: DIS4R0UE)

Disease Name	Traveler's diarrhea
Synonyms	Pica eating disorder; Pica
Disease Class	ME05: Bowel habit change
Definition	An eating disorder characterized by the persistent eating of nonnutritive substances such as clay or soil; this behavior must be inappropriate to the level of the individual's development.
Disease Hierarchy	DISVGXN0: Eating disorder DIS4R0UE: Traveler's diarrhea
ICD Code	ICD-11 ICD-11: ME05.1 ICD-9 ICD-9: 001-139, 787.91 Expand ICD-9 001,002,003,004,005,006,007,008,009,010,011,012,013,014,015,016,017,018,019,020,021,022,023,024,025,026,027,028,029,030,031,032,033,034,035,036,037,038,039,040,041,042,043,044,045,046,047,048,049,050,051,052,053,054,055,056,057,058,059,060,061,062,063,064,065,066,067,068,069,070,071,072,073,074,075,076,077,078,079,080,081,082,083,084,085,086,087,088,089,090,091,092,093,094,095,096,097,098,099,100,101,102,103,104,105,106,107,108,109,110,111,112,113,114,115,116,117,118,119,120,121,122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,787.91
Disease Identifiers	MONDO ID MONDO_0001441 MESH ID D010842 UMLS CUI C0031873 MedGen ID 45917 HPO ID HP:0011856 SNOMED CT ID 14077003

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 4 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ciprofloxacin XR	DM2NLS9	Approved	Small molecular drug	[1]
Loperamide	DMOJZQ9	Approved	Small molecular drug	[2]
Norfloxacin	DMIZ6W2	Approved	Small molecular drug	[3]
Ofloxacin	DM0VQN3	Approved	Small molecular drug	[4]
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This Disease is Treated as An Indication in 2 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
ACAM-Cdiff	DMH5LHV	Phase 2	Vaccine	[5]
LMN-101	DM0AQ3D	Phase 2	NA	[6]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
DEAF1	OTCLX3ZW	Strong	Genetic Variation	[7]
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References

1	A standard database for drug repositioning. Sci Data. 2017 Mar 14;4:170029.
2	Loperamide FDA Label
3	Norfloxacin FDA Label
4	Ofloxacin FDA Label
5	ClinicalTrials.gov (NCT00772343) Study of a Clostridium Difficile Toxoid Vaccine (ACAM-CDIFF in Subjects With Clostridium Difficile Infection. U.S. National Institutes of Health.
6	ClinicalTrials.gov (NCT04182490) A Phase 2 Randomized, Double-Blind, Placebo-Controlled, Single Dose Regimen Study of LMN-101 in Healthy Volunteers Challenged With Campylobacter Jejuni. U.S.National Institutes of Health.
7	Exome analysis of Smith-Magenis-like syndrome cohort identifies de novo likely pathogenic variants. Hum Genet. 2017 Apr;136(4):409-420. doi: 10.1007/s00439-017-1767-x. Epub 2017 Feb 17.