Details of Disease

General Information of Disease (ID: DIS4UTK4)

Disease Name Hearing disorder
Synonyms disorder of hearing; auditory alteration; hearing disorder
Disease Class AB50-AB57: Hearing disorder
Definition
A disorder characterized by the partial or complete loss of the ability to detect sounds due to damage to the ear structures or inability of the brain to properly interpret or process the auditory signals it receives from the anatomic structures of the ear.
Disease Hierarchy
DISH7H5I: Human disease
DISQRMRD: Auditory system disorder
DISHEDII: Perceptual disorders
DIS4UTK4: Hearing disorder
ICD Code
ICD-11
ICD-11: AB50-AB57
Disease Identifiers
MONDO ID
MONDO_0021945
MESH ID
D006311
UMLS CUI
C0260662
MedGen ID
82636
SNOMED CT ID
128540005

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Investigative Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
AHL DMVZLIB Investigative siRNA drug [1]
TherAtoH DM4CAEK Investigative NA [2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
NIPBL OTF6OOLU Strong Biomarker [3]
SRRM4 OTALUISN Strong Biomarker [4]
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References

1 Phase 2 randomized study of p53 antisense oligonucleotide (cenersen) plus idarubicin with or without cytarabine in refractory and relapsed acute myeloid leukemia. Cancer. 2012 Jan 15;118(2):418-27.
2 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
3 Multiple organ system defects and transcriptional dysregulation in the Nipbl(+/-) mouse, a model of Cornelia de Lange Syndrome.PLoS Genet. 2009 Sep;5(9):e1000650. doi: 10.1371/journal.pgen.1000650. Epub 2009 Sep 18.
4 Stereotypic circling behavior in mice with vestibular dysfunction: asymmetrical effects of intrastriatal microinjection of a dopamine agonist.Int J Neurosci. 2007 Jul;117(7):1049-64. doi: 10.1080/00207450600936874.