Details of Disease
General Information of Disease (ID: DIS5TAF4)
| Disease Name | ACTH-dependent Cushing syndrome | |||||
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| Synonyms |
pituitary Cushing diseases; pituitary Cushing disease; pituitary Cushing syndrome; adrenocorticotropic hormone, inappropriate secretion; ACTH hypersecretion, pituitary; pituitary-dependent Cushing's disease; pituitary-dependent Cushing disease; adrenocorticotropic hormone-dependent Cushing syndrome; overproduction of ACTH; corticotropin-dependent Cushing syndrome; ACTH-dependent CS
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| Definition |
Adrenocorticotropic hormone dependent Cushing syndrome (ACTH-dependent CS) is a form of endogenous CS caused by abnormal production of ACTH due, in 80% of cases, to ACTH oversecretion by a pituitary adenoma (Cushing disease, CD) and in 20% of cases to ectopic ACTH secretion (CS due to EAS) by an extrapituitary tumor (in 50% of cases originating in the lungs or less commonly in the thymus, pancreas, adrenal gland or thyroid) or very rarely due to a tumor secreting both ACTH and corticotrophin-releasing hormone (CRH).
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