Details of Disease | DrugMAP

General Information of Disease (ID: DIS6HGXF)

Disease Name	Brugada syndrome 9
Synonyms	KCND3 Brugada syndrome; Brugada syndrome caused by mutation in KCND3; BRGDA9; Brugada syndrome type 9; Brugada syndrome 9
Definition	Any Brugada syndrome in which the cause of the disease is a mutation in the KCND3 gene.
Disease Hierarchy	DISSGN0E: Brugada syndrome DIS6HGXF: Brugada syndrome 9
Disease Identifiers	MONDO ID MONDO_0014621 UMLS CUI C4225340 OMIM ID 616399 MedGen ID 903155

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
KCND3	TTPLQO0	Limited	Autosomal dominant	[1]
KCND3	TTPLQO0	Strong	Genetic Variation	[2]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
KCND3	OTRPIH7J	Limited	Autosomal dominant	[1]
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References

1	The Gene Curation Coalition: A global effort to harmonize gene-disease evidence resources. Genet Med. 2022 Aug;24(8):1732-1742. doi: 10.1016/j.gim.2022.04.017. Epub 2022 May 4.
2	Novel mutations in the KCND3-encoded Kv4.3 K+ channel associated with autopsy-negative sudden unexplained death.Hum Mutat. 2012 Jun;33(6):989-97. doi: 10.1002/humu.22058. Epub 2012 Mar 27.