General Information of Disease (ID: DIS6JEVM)

Disease Name Non-Langerhans cell histiocytosis
Synonyms histiocytosis, non-Langerhans-cell; non-Langerhans-cell histiocytosis
Definition
Group of disorders which feature accumulations of active HISTIOCYTES and LYMPHOCYTES, but where the histiocytes are not LANGERHANS CELLS. The group includes HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS; SINUS HISTIOCYTOSIS; xanthogranuloma; reticulohistiocytoma; juvenile XANTHOGRANULOMA; xanthoma disseminatum; as well as the lipid storage diseases (SEA-BLUE HISTIOCYTE SYNDROME; and NIEMANN-PICK DISEASES).
Disease Hierarchy
DISIYLND: Histiocytosis
DIS6JEVM: Non-Langerhans cell histiocytosis
Disease Identifiers
MONDO ID
MONDO_0015531
MESH ID
D015616
UMLS CUI
C0019624
MedGen ID
9265
Orphanet ID
157987

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ARAF TT5TURO Strong Genetic Variation [1]
------------------------------------------------------------------------------------

References

1 Diverse and Targetable Kinase Alterations Drive Histiocytic Neoplasms.Cancer Discov. 2016 Feb;6(2):154-65. doi: 10.1158/2159-8290.CD-15-0913. Epub 2015 Nov 13.