Details of Disease

General Information of Disease (ID: DIS6NFMB)

Disease Name Mast cell neoplasm
Synonyms
tumour of the Mast cells; tumour of Mast cells; tumor of the Mast cells; tumor of Mast cells; neoplasm of the Mast cells; neoplasm of Mast cells; mast cell tumour; mast cell tumor; mast cell neoplasm; Mast cell tumour; Mast cell tumor; Mast cell proliferative disease
Definition
A heterogeneous group of disorders characterized by the abnormal growth and accumulation of mast cells in one or more organ systems. Recent data suggest that most variants of mast cell neoplasms are clonal disorders. (WHO, 2001)
Disease Hierarchy
DISTBY9Z: Tumour
DIS2YOWO: Myeloid neoplasm
DIS6NFMB: Mast cell neoplasm
Disease Identifiers
MONDO ID
MONDO_0002724
UMLS CUI
C0334664
MedGen ID
83178
SNOMED CT ID
414653009

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 1 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
SLC5A6 TT61XTV Definitive Altered Expression [1]
------------------------------------------------------------------------------------
This Disease Is Related to 4 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CD72 OTPOJID2 Definitive Biomarker [2]
HS2ST1 OTHOU8I2 Definitive Biomarker [3]
IL27RA OTSQBAKI Definitive Altered Expression [4]
PLA2G2E OTGJ5XJR Definitive Biomarker [5]
------------------------------------------------------------------------------------

References

1 Biotin conjugated organic molecules and proteins for cancer therapy: A review.Eur J Med Chem. 2018 Feb 10;145:206-223. doi: 10.1016/j.ejmech.2018.01.001. Epub 2018 Jan 2.
2 CD72 regulates the growth of KIT-mutated leukemia cell line Kasumi-1.Sci Rep. 2013 Oct 4;3:2861. doi: 10.1038/srep02861.
3 Substrate specificity of the heparan sulfate hexuronic acid 2-O-sulfotransferase.Biochemistry. 2001 May 8;40(18):5548-55. doi: 10.1021/bi002926p.
4 Increased IL-27/IL-27R expression in association with the immunopathology of murine ocular toxoplasmosis.Parasitol Res. 2018 Jul;117(7):2255-2263. doi: 10.1007/s00436-018-5914-7. Epub 2018 May 19.
5 Arachidonate release and eicosanoid generation by group IIE phospholipase A(2).Biochem Biophys Res Commun. 2002 Apr 5;292(3):689-96. doi: 10.1006/bbrc.2002.6716.