Details of Disease | DrugMAP

General Information of Disease (ID: DIS6VKD0)

Disease Name	Spermatogenic failure 17
Synonyms	Male infertility due to oocyte Activation failure; spermatogenic failure 17; SPGF17; SPGF17; spermatogenic failure type 17; PLCZ1 azoospermia; spermatogenic failure 17; azoospermia caused by mutation in PLCZ1
Definition	Any azoospermia in which the cause of the disease is a mutation in the PLCZ1 gene.
Disease Hierarchy	DIS3D1AI: Spermatogenic failure DIS6VKD0: Spermatogenic failure 17
Disease Identifiers	MONDO ID MONDO_0014970 UMLS CUI C4310666 OMIM ID 617214 MedGen ID 934633

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PLCZ1	OTJ2MEFA	Strong	Autosomal recessive	[1]
------------------------------------------------------------------------------------

References

1	Reduced amounts and abnormal forms of phospholipase C zeta (PLCzeta) in spermatozoa from infertile men. Hum Reprod. 2009 Oct;24(10):2417-28. doi: 10.1093/humrep/dep207. Epub 2009 Jul 7.