Details of Disease | DrugMAP

General Information of Disease (ID: DIS87ANI)

Disease Name	Leukemia, acute lymphoblastic, susceptibility to, 3
Synonyms	susceptibility to acute lymphoblastic leukaemia 3; susceptibility to acute lymphoblastic leukemia 3; ALL3; leukemia, acute lymphoblastic, susceptibility to, 3; precursor B-cell acute lymphoblastic leukemia caused by mutation in PAX5; precursor B-cell acute lymphoblastic leukaemia caused by mutation in PAX5; PAX5 precursor B-cell acute lymphoblastic leukemia; PAX5 precursor B-cell acute lymphoblastic leukaemia; leukemia, acute lymphoblastic, susceptibility to, type 3
Definition	Any precursor B-cell acute lymphoblastic leukemia in which the cause of the disease is a mutation in the PAX5 gene.
Disease Hierarchy	DISGXLG5: Hereditary neoplastic syndrome DIS98MYE: Inherited disease susceptibility DIS87ANI: Leukemia, acute lymphoblastic, susceptibility to, 3
Disease Identifiers	MONDO ID MONDO_0014241 UMLS CUI C3809874 OMIM ID 615545 MedGen ID 816204

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
PAX5	TTA4REJ	Moderate	Autosomal dominant	[1]
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This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
PAX5	OTYBJJWX	Moderate	Autosomal dominant	[1]
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References

1	Classification of Genes: Standardized Clinical Validity Assessment of Gene-Disease Associations Aids Diagnostic Exome Analysis and Reclassifications. Hum Mutat. 2017 May;38(5):600-608. doi: 10.1002/humu.23183. Epub 2017 Feb 13.