Details of Disease | DrugMAP

General Information of Disease (ID: DIS9KPML)

Disease Name	Colorectal cancer, hereditary nonpolyposis, type 7
Synonyms	HNPCC7; MLH3 hereditary nonpolyposis colon cancer; colorectal cancer, hereditary nonpolyposis, type 7; hereditary nonpolyposis colon cancer caused by mutation in MLH3
Definition	Any hereditary nonpolyposis colon cancer in which the cause of the disease is a mutation in the MLH3 gene.
Disease Hierarchy	DISPA49R: Hereditary nonpolyposis colon cancer DIS3HIWD: Autosomal dominant disease DIS9KPML: Colorectal cancer, hereditary nonpolyposis, type 7
Disease Identifiers	MONDO ID MONDO_0013725 MESH ID C565777 UMLS CUI C1858380 OMIM ID 614385 MedGen ID 346893

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
MLH3	OT91PPBI	Moderate	Autosomal dominant	[1]
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References

1	Technical standards for the interpretation and reporting of constitutional copy-number variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics (ACMG) and the Clinical Genome Resource (ClinGen). Genet Med. 2020 Feb;22(2):245-257. doi: 10.1038/s41436-019-0686-8. Epub 2019 Nov 6.