Details of Disease

General Information of Disease (ID: DIS9S8BC)

Disease Name Lymphoid neoplasm
Synonyms
lymphoid and plasma cell tumour; lymphocytic tumour; lymphoid tumor; lymphocytic tumor; lymphocytic and plasma cell neoplasm; lymphocytic and plasmacytic neoplasm; lymphoid and plasmacytic neoplasm; lymphoid neoplasm; lymphocytic and plasma cell tumor; lymphoid and plasmacytic tumor; lymphoid and plasmacytic tumour; lymphocytic and plasma cell tumour; lymphocytic neoplasm; lymphoid tumour; lymphoid and plasma cell tumor
Definition
A neoplasm composed of a lymphocytic cell population which is usually malignant (clonal) by molecular genetic and/or immunophenotypic analysis. Lymphocytic neoplasms include Hodgkin and non-Hodgkin lymphomas, acute and chronic lymphocytic leukemias, and plasma cell neoplasms.
Disease Hierarchy
DISCDP7W: Haematological malignancy
DIS9S8BC: Lymphoid neoplasm
Disease Identifiers
MONDO ID
MONDO_0005157
UMLS CUI
C0598798
MedGen ID
108626
SNOMED CT ID
414628006

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
ATM TTKBM7V moderate Biomarker [1]
FLT3 TTGJCWZ Strong Genetic Variation [2]
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This Disease Is Related to 3 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
TRIP11 OT4FJEAR Limited Genetic Variation [2]
CDCA7 OT12HDZY Strong Altered Expression [3]
TCP1 OT1MGUX9 Strong Biomarker [4]
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References

1 Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage.J Leukoc Biol. 2017 Apr;101(4):927-947. doi: 10.1189/jlb.4VMA0716-316R. Epub 2016 Nov 28.
2 A novel TRIP11-FLT3 fusion in a patient with a myeloid/lymphoid neoplasm with eosinophilia.Cancer Genet. 2017 Oct;216-217:10-15. doi: 10.1016/j.cancergen.2017.05.001. Epub 2017 May 10.
3 CDCA7 is a critical mediator of lymphomagenesis that selectively regulates anchorage-independent growth.Haematologica. 2018 Oct;103(10):1669-1678. doi: 10.3324/haematol.2018.188961. Epub 2018 Jun 7.
4 Silencing P2X7 receptor downregulates the expression of TCP-1 involved in lymphoma lymphatic metastasis.Oncotarget. 2015 Dec 8;6(39):42105-17. doi: 10.18632/oncotarget.5870.