Details of Disease | DrugMAP

General Information of Disease (ID: DIS9V2II)

Disease Name	Autosomal dominant nonsyndromic hearing loss 4B
Synonyms	deafness, autosomal dominant 4B; autosomal dominant deafness 4B; deafness, autosomal dominant 4b; autosomal dominant nonsyndromic deafness caused by mutation in CEACAM16; autosomal dominant nonsyndromic deafness type 4B; DFNA4B; deafness, autosomal dominant type 4B; autosomal dominant nonsyndromic deafness 4B; CEACAM16 autosomal dominant nonsyndromic deafness
Definition	Any autosomal dominant nonsyndromic deafness in which the cause of the disease is a mutation in the CEACAM16 gene.
Disease Hierarchy	DISYC1G0: Autosomal dominant nonsyndromic hearing loss DIS9V2II: Autosomal dominant nonsyndromic hearing loss 4B
Disease Identifiers	MONDO ID MONDO_0013823 UMLS CUI C3281297 OMIM ID 614614 MedGen ID 482927

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
CEACAM16	OTUMUSY0	Strong	Autosomal dominant	[1]
------------------------------------------------------------------------------------

References

1	Carcinoembryonic antigen-related cell adhesion molecule 16 interacts with alpha-tectorin and is mutated in autosomal dominant hearing loss (DFNA4). Proc Natl Acad Sci U S A. 2011 Mar 8;108(10):4218-23. doi: 10.1073/pnas.1005842108. Epub 2011 Feb 22.