Details of Disease

General Information of Disease (ID: DISCZ298)

• Disease Name: Precursor T-lymphoblastic lymphoma/leukemia
• Synonyms: precursor T-lymphoblastic lymphoma/leukemia; precursor T lymphoblastic lymphoma/leukemia; precursor T lymphoblastic leukemia/lymphoma; T lymphoblastic leukemia/lymphoma
• Definition: A neoplasm of lymphoblasts committed to the T-cell lineage, typically composed of small to medium-sized blast cells. When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called T acute lymphoblastic leukemia. When it involves nodal or extranodal sites it is called T lymphoblastic lymphoma. (WHO, 2001)
• Disease Hierarchy:
  DIS1X51P: Precursor lymphoblastic lymphoma/leukemia
  DIS1UOF2: T-cell and NK-cell neoplasm
  DISCZ298: Precursor T-lymphoblastic lymphoma/leukemia
• Disease Identifiers:
  MONDO ID: MONDO_0003537
  UMLS CUI: C1301359
  MedGen ID: 224897
  SNOMED CT ID: 397348006

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 2 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
FLT3	TTGJCWZ	Limited	Biomarker	[1]
PSMB5	TT68GPI	Strong	Altered Expression	[2]

This Disease Is Related to 1 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
FIP1L1	OTF91GTL	Strong	Biomarker	[3]

References

• [1] Flow cytometric characterization of acute leukemia reveals a distinctive "blast gate" of murine T-lymphoblastic leukemia/lymphoma.Oncotarget. 2017 Dec 18;9(2):2320-2328. doi: 10.18632/oncotarget.23410. eCollection 2018 Jan 5.
• [2] Overexpression of the PSMB5 gene contributes to bortezomib resistance in T-lymphoblastic lymphoma/leukemia cells derived from Jurkat line.Exp Hematol. 2008 Oct;36(10):1278-84. doi: 10.1016/j.exphem.2008.04.013. Epub 2008 Jun 17.
• [3] A neoplasm with FIP1L1-PDGFRA fusion presenting as pediatric T-cell lymphoblastic leukemia/lymphoma without eosinophilia.Cancer Genet. 2017 Oct;216-217:91-99. doi: 10.1016/j.cancergen.2017.07.007. Epub 2017 Aug 3.