Details of Disease

General Information of Disease (ID: DISFC6MM)

Disease Name Digestive system carcinoma
Synonyms gastrointestinal system carcinoma; carcinoma of the gastrointestinal system; digestive system carcinoma; gastrointestinal carcinoma (disease); carcinoma of digestive system; gastrointestinal carcinoma
Definition A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma.
Disease Hierarchy
DIS3AOQ7: Aerodigestive tract cancer
DISH9F1N: Carcinoma
DISFC6MM: Digestive system carcinoma
Disease Identifiers
MONDO ID
MONDO_0006181
UMLS CUI
C0151544
MedGen ID
57467
HPO ID
HP:0002672

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
GUCY2C TTLDPRG Strong Genetic Variation [1]
PLOD1 TTEKJP3 Definitive Altered Expression [2]
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This Disease Is Related to 1 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
DOCK1 OTCFV3ON Strong Genetic Variation [3]
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References

1 TAK-264 (MLN0264) in Previously Treated Asian Patients with Advanced Gastrointestinal Carcinoma Expressing Guanylyl Cyclase C: Results from an Open-Label, Non-randomized Phase 1 Study.Cancer Res Treat. 2018 Apr;50(2):398-404. doi: 10.4143/crt.2017.074. Epub 2017 May 10.
2 High Expression of PLOD1 Drives Tumorigenesis and Affects Clinical Outcome in Gastrointestinal Carcinoma.Genet Test Mol Biomarkers. 2018 Jun;22(6):366-373. doi: 10.1089/gtmb.2018.0009. Epub 2018 May 3.
3 Body mass index change in gastrointestinal cancer and chronic obstructive pulmonary disease is associated with Dedicator of Cytokinesis 1.J Cachexia Sarcopenia Muscle. 2017 Jun;8(3):428-436. doi: 10.1002/jcsm.12171. Epub 2017 Jan 2.