Details of Disease

General Information of Disease (ID: DISGAJIG)

• Disease Name: Overnutrition
• Definition: An imbalanced nutritional status resulting from excessive intake of nutrients. Generally, overnutrition generates an energy imbalance between food consumption and energy expenditure leading to disorders such as obesity.
• Disease Hierarchy:
  DIS0W6QK: Nutritional disorder
  DISGAJIG: Overnutrition
• Disease Identifiers:
  MONDO ID: MONDO_0003916
  MESH ID: D044343
  UMLS CUI: C1257763
  MedGen ID: 219760
  SNOMED CT ID: 302872003

Molecular Interaction Atlas (MIA) of This Disease

This Disease Is Related to 3 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
GIP	TT40HS5	Strong	Biomarker	[1]
GIPR	TTYMKBE	Strong	Biomarker	[1]
MCHR1	TTX4RTB	Strong	Altered Expression	[2]

This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BLVRB	OTHCFN2C	Limited	Altered Expression	[3]
GPAM	OTR1XD9B	Strong	Altered Expression	[4]
LHB	OT5GBOVJ	Strong	Altered Expression	[5]
MOGAT1	OTZP43K4	Strong	Genetic Variation	[6]
ECHS1	OTS0593S	Definitive	Biomarker	[7]

References

• [1] Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition.J Clin Invest. 2019 Aug 12;129(9):3786-3791. doi: 10.1172/JCI126107. eCollection 2019 Aug 12.
• [2] Postnatal overnutrition alters the orexigenic effects of melanin-concentrating hormone (MCH) and reduces MCHR1 hypothalamic expression on spontaneous feeding and fasting.Pharmacol Biochem Behav. 2018 Dec;175:53-61. doi: 10.1016/j.pbb.2018.09.002. Epub 2018 Sep 6.
• [3] Growth hormone-binding proteins in plasma.Nutrition. 1993 Nov-Dec;9(6):546-53.
• [4] Thioesterase superfamily member 2 promotes hepatic insulin resistance in the setting of glycerol-3-phosphate acyltransferase 1-induced steatosis.J Biol Chem. 2019 Feb 8;294(6):2009-2020. doi: 10.1074/jbc.RA118.005184. Epub 2018 Dec 6.
• [5] Neonatal Overnutrition Increases Testicular Size and Expression of Luteinizing Hormone -Subunit in Peripubertal Male Rats.Front Endocrinol (Lausanne). 2018 Apr 13;9:168. doi: 10.3389/fendo.2018.00168. eCollection 2018.
• [6] Epigenetic programming at the Mogat1 locus may link neonatal overnutrition with long-term hepatic steatosis and insulin resistance.FASEB J. 2018 May 29:fj201700717RR. doi: 10.1096/fj.201700717RR. Online ahead of print.
• [7] Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients.Nat Commun. 2017 Sep 6;8(1):464. doi: 10.1038/s41467-017-00489-5.