Details of Disease

General Information of Disease (ID: DISH6N87)

Disease Name Pure autonomic failure
Synonyms
idiopathic orthostatic hypotension (a symptom); orthostatic hypotension (a symptom); Bradbury-Eggleston syndrome; Pure idiopatic dysautonomia; idiopathic orthostatic hypotension; Pure dysautonomia; PAF; Bradbury Eggleston syndrome
Definition Pure autonomic failure (PAF) is a neurodegenerative disease that affects the sympathetic branch of the autonomous nervous system and that manifests with orthostatic hypotension.
Disease Hierarchy
DIS6JLTA: Autonomic nervous system disorder
DISASEYE: Multiple system atrophy
DISH6N87: Pure autonomic failure
Disease Identifiers
MONDO ID
MONDO_0018608
MESH ID
D054970
UMLS CUI
C0393911
MedGen ID
98293
Orphanet ID
441
SNOMED CT ID
84438001

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)
This Disease is Treated as An Indication in 2 Approved Drug(s)
Drug Name Drug ID Highest Status Drug Type REF
Droxidopa DM5YF4M Approved Small molecular drug [1]
Norepinephrine DMOUC09 Approved Small molecular drug [2]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
SNCA TT08OSU Limited Biomarker [3]
DBH TTYIP79 Strong Biomarker [4]
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References

1 Droxidopa FDA Label
2 Norepinephrine FDA Label
3 The catecholaldehyde hypothesis: where MAO fits in.J Neural Transm (Vienna). 2020 Feb;127(2):169-177. doi: 10.1007/s00702-019-02106-9. Epub 2019 Dec 5.
4 Norepinephrine deficiency is caused by combined abnormal mRNA processing and defective protein trafficking of dopamine beta-hydroxylase.J Biol Chem. 2011 Mar 18;286(11):9196-204. doi: 10.1074/jbc.M110.192351. Epub 2011 Jan 5.