Details of Disease | DrugMAP

General Information of Disease (ID: DISH7LPY)

Disease Name	Idiopathic interstitial pneumonia
Synonyms	IPF; noninfectious pneumonia; idiopathic interstitial pneumonitis; idiopathic fibrosing alveolitis; diffuse idiopathic pulmonary fibrosis; IIp
Definition	A class of diffuse lung diseases that typically affect the pulmonary interstitium, although some also have a component affecting the airways (for instance, Cryptogenic organizing pneumonitis).
Disease Hierarchy	DIS8EF3M: Pneumonia DISBBY0S: Idiopathic disease DISH7LPY: Idiopathic interstitial pneumonia
Disease Identifiers	MONDO ID MONDO_0002429 MESH ID D054988 UMLS CUI C2350236 MedGen ID 389939 Orphanet ID 98300 SNOMED CT ID 700249006

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 1 DTT Molecule(s)

Gene Name	DTT ID	Evidence Level	Mode of Inheritance	REF
SFTPD	TTGLMU7	Strong	Biomarker	[1]
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This Disease Is Related to 11 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
BMP3	OTCTI0UW	Limited	Altered Expression	[2]
MUC21	OTQ8GP5L	Limited	Biomarker	[3]
OVGP1	OTL2W9M5	Limited	Biomarker	[3]
PI15	OTPJL6ML	Limited	Biomarker	[4]
RTKN2	OTV2AXQM	Limited	Altered Expression	[4]
FAM13A	OTZ6GN0Q	moderate	Genetic Variation	[5]
HNRNPD	OT5UO1FA	Strong	Altered Expression	[6]
MUC5B	OTPW6K5C	Strong	Biomarker	[3]
PARN	OTTG4PE3	Strong	Biomarker	[7]
PCBP2	OTXCN9CG	Strong	Altered Expression	[6]
TIAL1	OTV2KFZH	Strong	Altered Expression	[6]
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⏷ Show the Full List of 11 DOT(s)

References

1	Evaluation of the Diagnostic Efficacies of Serological Markers KL-6, SP-A, SP-D, CCL2, and CXCL13 in Idiopathic Interstitial Pneumonia.Respiration. 2019;98(6):534-545. doi: 10.1159/000503689. Epub 2019 Oct 30.
2	Reduced expression of BMP3 contributes to the development of pulmonary fibrosis and predicts the unfavorable prognosis in IIP patients.Oncotarget. 2017 Aug 9;8(46):80531-80544. doi: 10.18632/oncotarget.20083. eCollection 2017 Oct 6.
3	Unique expression profiles of mucin proteins in interstitial pneumonia-associated lung adenocarcinomas.Histol Histopathol. 2019 Nov;34(11):1243-1254. doi: 10.14670/HH-18-114. Epub 2019 Apr 9.
4	Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias.BMC Genomics. 2015 Oct 26;16:869. doi: 10.1186/s12864-015-2102-3.
5	FAM13A polymorphism as a prognostic factor in patients with idiopathic pulmonary fibrosis.Respir Med. 2017 Feb;123:105-109. doi: 10.1016/j.rmed.2016.12.007. Epub 2016 Dec 22.
6	Expression Profile of Six RNA-Binding Proteins in Pulmonary Sarcoidosis.PLoS One. 2016 Aug 30;11(8):e0161669. doi: 10.1371/journal.pone.0161669. eCollection 2016.
7	Telomere-related lung fibrosis is diagnostically heterogeneous but uniformly progressive.Eur Respir J. 2016 Dec;48(6):1710-1720. doi: 10.1183/13993003.00308-2016. Epub 2016 Aug 18.