Details of Disease

General Information of Disease (ID: DISH8MNP)

• Disease Name: Scorpion envenoming syndrome
• Synonyms: poisoning due to scorpion venom; poisoning caused by scorpion venom; toxic effect of venom of scorpion
• Disease Class: 8D43: Neurological toxicity disorder
• Definition: Scorpion envenomation is a rare intoxication caused by a scorpion sting which typically manifests with localized pain, edema, erythema, and paresthesias at the site of the sting and, when severe, progresses to produce systemic symptoms of variable severity that include respiratory difficulties, abnormal systemic blood pressure, cardiac arrhythmia, and a combination of parasympathetic (i.e. excessive salivation and lacrimation, diaphoresis, miosis, frequent urination, diarrhea, vomiting, priapism) and sympathetic (e.g. hyperthermia, hyperglycemia, mydriasis) manifestations. Neurological manifestations may also be associated, such as abnormal eye movements, blurred vision, agitation and restlessness, as well as muscle fasciculations and spasms. Signs and symptoms are highly variable and in most severe cases may lead to cardiogenic shock and pulmonary edema.
• Disease Hierarchy:
  DIS7OPRV: Intoxication
  DISH8MNP: Scorpion envenoming syndrome
• ICD Code:
  ICD-11: ICD-11: 8D43
  ICD-9: ICD-9: 989.5
  Expand ICD-9: 989.5

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 1 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Charybdotoxin	DMKN345	Approved	Small molecular drug	[1]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2328).