Details of Disease

General Information of Disease (ID: DISL7CZV)

Disease Name Periodontitis, aggressive 1
Synonyms periodontitis, aggressive, 1; periodontitis, juvenile; periodontitis, prepubertal; juvenile periodontitis; periodontitis, aggressive, type 1; periodontitis 1, juvenile
Definition
A localized aggressive periodontitis, formerly called localized juvenile periodontitis. It is a destructive form of periodontitis characterized by ALVEOLAR BONE LOSS of the MOLARS and INCISORS. Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people.
Disease Hierarchy
DIS0FJ2N: CTSC-related disorder
DISJKAFL: Chronic periodontitis
DISL7CZV: Periodontitis, aggressive 1
Disease Identifiers
MONDO ID
MONDO_0008226
MESH ID
D010520
UMLS CUI
C4551681
OMIM ID
170650
MedGen ID
1644602

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 2 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CTSC TTQ9J6R Limited Unknown [1]
CTSC TT4H0V2 Strong Biomarker [2]
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This Disease Is Related to 1 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CTSC OT79WJZZ Limited Unknown [1]
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References

1 The role of cathepsin C in Papillon-Lefvre syndrome, prepubertal periodontitis, and aggressive periodontitis. Hum Mutat. 2004 Mar;23(3):222-8. doi: 10.1002/humu.10314.
2 Advantages and pitfalls of an extended gene panel for investigating complex neurometabolic phenotypes.Brain. 2016 Nov 1;139(11):2844-2854. doi: 10.1093/brain/aww221.