Details of Disease

General Information of Disease (ID: DISLAE1V)

• Disease Name: Multidrug resistant infection
• Disease Class: MG50-MG52: Antimicrobial drug resistance
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DISLAE1V: Multidrug resistant infection
• ICD Code:
  ICD-11: ICD-11: MG51
  ICD-10: ICD-10: A00-B99

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
SPR206	DM73BLS	Phase 1	Small molecular drug	[1]
TP 6076	DMD0NA1	Phase 1	Small molecular drug	[2]
TP-6076	DM5RIT8	Phase 1	Small interfering RNA	[2]

This Disease is Treated as An Indication in 1 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Ro-48-8724	DM0RZEO	Terminated	NA	[3]

This Disease is Treated as An Indication in 1 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
LpxCi-4	DMH5RQL	Investigative	NA	[4]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] Clinical pipeline report, company report or official report of Spero Therapeutics.
• [2] ClinicalTrials.gov (NCT03691584) Phase 1, Safety and Bronchopulmonary PK Study in Healthy Volunteers (BAL). U.S. National Institutes of Health.
• [3] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008187)
• [4] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.