Details of Disease

General Information of Disease (ID: DISLMV1J)

Disease Name Non-immunoglobulin-mediated membranoproliferative glomerulonephritis
Synonyms non-immunoglobulin-mediated MPGN; non-Ig-mediated membranoproliferative glomerulonephritis; C3 glomerulopathy; non-Ig-mediated MPGN
Disease Hierarchy
DISW087P: Primary membranoproliferative glomerulonephritis
DISLMV1J: Non-immunoglobulin-mediated membranoproliferative glomerulonephritis
Disease Identifiers
MONDO ID
MONDO_0018013
UMLS CUI
C4087273
MedGen ID
1672497
Orphanet ID
329918

Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)
This Disease Is Related to 6 DTT Molecule(s)
Gene Name DTT ID Evidence Level Mode of Inheritance REF
CD46 TTMS7DF Limited Genetic Variation [1]
C3 TTJGY7A Strong Biomarker [2]
CFB TTA0P7K Strong Biomarker [3]
CFH TTUW6OP Strong Genetic Variation [4]
CFI TT6ATLX Strong Biomarker [5]
CFP TTLA0VS Strong Genetic Variation [6]
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⏷ Show the Full List of 6 DTT(s)
This Disease Is Related to 6 DOT Molecule(s)
Gene Name DOT ID Evidence Level Mode of Inheritance REF
CFHR1 OT72R16T Strong Genetic Variation [7]
CFHR2 OTACE5Y1 Strong Biomarker [5]
CFHR3 OTYL8SDO Strong Genetic Variation [8]
CFHR5 OT7BMOYE Strong Biomarker [9]
DGKE OTWS86AS Strong Biomarker [10]
NLRP12 OTGR132Z Strong Genetic Variation [11]
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⏷ Show the Full List of 6 DOT(s)

References

1 Complement gene variants determine the risk of immunoglobulin-associated MPGN and C3 glomerulopathy and predict long-term renal outcome.Mol Immunol. 2016 Mar;71:131-142. doi: 10.1016/j.molimm.2016.01.010. Epub 2016 Feb 16.
2 C3-Glomerulopathy Autoantibodies Mediate Distinct Effects on Complement C3- and C5-Convertases.Front Immunol. 2019 May 31;10:1030. doi: 10.3389/fimmu.2019.01030. eCollection 2019.
3 High-Throughput Genetic Testing for Thrombotic Microangiopathies and C3 Glomerulopathies.J Am Soc Nephrol. 2016 Apr;27(4):1245-53. doi: 10.1681/ASN.2015040385. Epub 2015 Aug 17.
4 Complete functional characterization of disease-associated genetic variants in the complement factor H gene.Kidney Int. 2018 Feb;93(2):470-481. doi: 10.1016/j.kint.2017.07.015. Epub 2017 Sep 21.
5 Reclassification of membranoproliferative glomerulonephritis: Identification of a new GN: C3GN.World J Nephrol. 2016 Jul 6;5(4):308-20. doi: 10.5527/wjn.v5.i4.308.
6 Prevention of Fatal C3 Glomerulopathy by Recombinant Complement Receptor of the Ig Superfamily.J Am Soc Nephrol. 2018 Aug;29(8):2053-2059. doi: 10.1681/ASN.2018030270. Epub 2018 Jun 12.
7 A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy.Kidney Int. 2017 Oct;92(4):876-887. doi: 10.1016/j.kint.2017.04.025. Epub 2017 Jul 18.
8 A hybrid CFHR3-1 gene causes familial C3 glomerulopathy. J Am Soc Nephrol. 2012 Jul;23(7):1155-60. doi: 10.1681/ASN.2012020166. Epub 2012 May 24.
9 FHR5 Binds to Laminins, Uses Separate C3b and Surface-Binding Sites, and Activates Complement on Malondialdehyde-Acetaldehyde Surfaces.J Immunol. 2018 Apr 1;200(7):2280-2290. doi: 10.4049/jimmunol.1701641. Epub 2018 Feb 26.
10 The Phenotypic Spectrum of Nephropathies Associated with Mutations in Diacylglycerol Kinase .J Am Soc Nephrol. 2017 Oct;28(10):3066-3075. doi: 10.1681/ASN.2017010031. Epub 2017 May 19.
11 C3 glomerulopathy in NLRP12-related autoinflammatory disorder: case-based review.Rheumatol Int. 2018 Aug;38(8):1571-1576. doi: 10.1007/s00296-018-4092-3. Epub 2018 Jun 27.