Details of Disease

General Information of Disease (ID: DISMMXUS)

• Disease Name: Ocular disease
• Disease Class: 1F00: Herpes simplex infection
• Disease Hierarchy:
  DIS01GPL: Grass pollen hypersensitivity
  DISMMXUS: Ocular disease
• ICD Code: ICD-11: ICD-11: 1F00.1Z

Drug-Interaction Atlas (DIA) of This Disease

This Disease is Treated as An Indication in 3 Approved Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
FLUORESCEIN	DMQTFAO	Approved	Small molecular drug	[1]
Latanoprost	DMI5OXG	Approved	Small molecular drug	[2]
Tetrahydrozoline	DMT57WC	Approved	Small molecular drug	[3]

This Disease is Treated as An Indication in 6 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AAV2-hRPE65v2	DMJNSLU	Phase 3	NA	[4]
Mapracorat	DMR23M1	Phase 3	Small molecular drug	[5]
ESBA-105	DMYZWDC	Phase 2	Antibody	[6]
RX-10045	DMDDWE5	Phase 2	NA	[7]
MA09-hRPE cells	DMDNBJ1	Phase 1/2	NA	[8]
PG-545	DM68D3O	Phase 1	?	[9]

This Disease is Treated as An Indication in 4 Discontinued Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
15(S)-hydroxyeicosatetraenoic acid (ophthalmic, dry eye), Alcon	DMUM3CP	Discontinued in Phase 3	Small molecular drug	[10]
F-200	DMVWZN1	Terminated	Small molecular drug	[11]
PS-388023	DM8P05S	Terminated	NA	[12]
Troponin-I	DM5OWAM	Terminated	NA	[13]

This Disease is Treated as An Indication in 19 Investigative Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
AR-12432	DMI4D0T	Investigative	NA	[14]
AV-2	DM1NKGU	Investigative	NA	[14]
CLT-011	DMBSRCS	Investigative	NA	[14]
ESBA-903	DMDNBWZ	Investigative	NA	[14]
GTx-822	DMEIMVW	Investigative	NA	[15]
IXS-312	DM3LT09	Investigative	NA	[14]
LRN-672	DM1012Z	Investigative	NA	[14]
MAT-302	DM6UELQ	Investigative	NA	[14]
MC-4001	DMGFL63	Investigative	NA	[14]
MIM-3Aa	DM3V7PV	Investigative	NA	[14]
MIM-3Ae	DMPWJVH	Investigative	NA	[14]
MP-0260	DM8ZZY0	Investigative	NA	[14]
NV.AT.08	DMXJR0C	Investigative	NA	[14]
NV.RYM.09	DMIC6DO	Investigative	NA	[14]
PAN-90716-DES	DMY9YIP	Investigative	NA	[14]
PRS-040	DMF0ZOI	Investigative	NA	[14]
RX-20001	DMGIL9R	Investigative	Small molecular drug	[14]
SMK-01/03	DMJT9KL	Investigative	NA	[14]
STP-601	DMLWYR5	Investigative	NA	[14]

Molecular Interaction Atlas (MIA) of This Disease

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 344).
• [3] Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline. Clin Toxicol (Phila). 2008 Feb;46(2):171-2.
• [4] ClinicalTrials.gov (NCT00999609) Safety and Efficacy Study in Subjects With Leber Congenital Amaurosis. U.S. National Institutes of Health.
• [5] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8643).
• [6] ClinicalTrials.gov (NCT00823173) Exploratory Study on Topical ESBA105 in Acute Anterior Uveitis. U.S. National Institutes of Health.
• [7] ClinicalTrials.gov (NCT01675570) A Study of RX-10045 in the Treatment of Dry Eye Disease. U.S. National Institutes of Health.
• [8] ClinicalTrials.gov (NCT01345006) Sub-retinal Transplantation of hESC Derived RPE(MA09-hRPE)Cells in Patients With Stargardt's Macular Dystrophy. U.S. National Institutes of Health.
• [9] PG545, a dual heparanase and angiogenesis inhibitor, induces potent anti-tumour and anti-metastatic efficacy in preclinical models. Br J Cancer. 2011 Feb 15;104(4):635-42.
• [10] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3401).
• [11] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800018439)
• [12] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022665)
• [13] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009227)
• [14] The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
• [15] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 621).