Details of Disease

Disease Name

Streptococcal B infection

Disease Class

1G40-1G41: Sepsis

Disease Hierarchy

DIS01GPL: Grass pollen hypersensitivity

DISN80QT: Streptococcal B infection

ICD-11

ICD-11: 1G40

Disease Identifiers

MONDO ID

MONDO_0700218

MESH ID

D013290

UMLS CUI

C2020625

MedGen ID

378336

SNOMED CT ID

426933007

General Information of Disease (ID: DISN80QT)

Drug-Interaction Atlas (DIA) of This Disease

Drug-Interaction Atlas (DIA)

This Disease is Treated as An Indication in 1 Clinical Trial Drug(s)

Drug Name	Drug ID	Highest Status	Drug Type	REF
Streptococcal B conjugated vaccine	DMVFY94	Phase 2	NA	[1]
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Molecular Interaction Atlas (MIA) of This Disease

Molecular Interaction Atlas (MIA)

This Disease Is Related to 5 DOT Molecule(s)

Gene Name	DOT ID	Evidence Level	Mode of Inheritance	REF
FTSJ1	OTNE7W96	Limited	Biomarker	[2]
FTSJ3	OT3J8P0B	Limited	Biomarker	[2]
GOLGA4	OTCMEHNJ	Limited	Biomarker	[3]
SIGLEC14	OT2JGGXD	Limited	Biomarker	[4]
SIGLEC9	OTZC7SIM	Limited	Biomarker	[5]
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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Subtractive hybridization identifies a novel predicted protein mediating epithelial cell invasion by virulent serotype III group B Streptococcus agalactiae.Infect Immun. 2003 Dec;71(12):6857-63. doi: 10.1128/IAI.71.12.6857-6863.2003.
3	Decidualization Mediated by Steroid Hormones Modulates the Innate Immunity in Response to Group B Streptococcal Infection in vitro.Gynecol Obstet Invest. 2017;82(6):592-600. doi: 10.1159/000454770. Epub 2017 Feb 2.
4	Siglec-14 Enhances NLRP3-Inflammasome Activation in Macrophages.J Innate Immun. 2020;12(4):333-343. doi: 10.1159/000504323. Epub 2019 Dec 5.
5	Implication of Soluble Forms of Cell Adhesion Molecules in Infectious Disease and Tumor: Insights from Transgenic Animal Models.Int J Mol Sci. 2018 Jan 13;19(1):239. doi: 10.3390/ijms19010239.